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0U2AF1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionSplicing factor u2af 35 kda subunit (u2 auxiliary factor 35 kda subunit) (u2 snrnp auxiliary factor small subunit).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0015030 Cajal body (TAS)
0006397 mRNA processing (TAS)
0008380 RNA splicing (TAS)

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Domain Architecture (Details)
InterPro domains unassigned to SynO:
This entry represents nucleotide-binding domains with an alpha-beta plait structure.hich consists of either a ferredoxin-like (beta-alpha-beta)2 fold.uch as that found in RNA-binding domains of various ribonucleoproteins or in viral DNA-binding domains . or a beta-(alpha)-beta-alpha-beta(2) fold.uch as that found in the ribosomal protein L23 .
  IPR012677:Nucleotide-binding, alpha-beta plait
Zinc finger domains are thought to be involved in DNA-binding.nd exist as different types.epending on thepositions of the cysteine residues. Proteins containing zinc finger domains of the C-x8-C-x5-C-x3-H type include zincfinger proteins from eukaryotes involved in cell cycle or growth phase-related regulation..g. human TIS11B(butyrate response factor 1). probable regulatory protein involved in regulating the response to growth factors.nd the mouse TTP growth factor-inducible nuclear protein.hich has the same function. The mouse TTP proteinis induced by growth factors. Another protein containing this domain is the human splicing factor U2AF 35 kDsubunit.hich plays a critical role in both constitutive and enhancer-dependent splicing by mediating essentialprotein-protein interactions and protein-RNA interactions required for 3 splice site selection. It has beenshown that different CCCH zinc finger proteins interact with the 3untranslated region of various mRNA . This type of zinc finger is very often present in twocopies.
  IPR000571:Zinc finger, CCCH-type
Many eukaryotic proteins that are known or supposed to bind single-stranded RNA contain one or more copies of a putative RNA-binding domain of about 90 amino acids. This is known as the eukaryotic putative RNA-binding region RNP-1 signature or RNA recognition motif (RRM). RRMs are found in a variety of RNA binding proteins.ncluding heterogeneous nuclear ribonucleoproteins (hnRNPs).roteins implicated in regulation of alternative splicing.nd protein components of small nuclear ribonucleoproteins (snRNPs). The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialized features for protein recognition . The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich.ith a third helix present during RNA binding in some cases .
  IPR000504:RNA-binding region RNP-1 (RNA recognition motif)
The U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) is aheterodimeric splicing factor composed of a large and a small subunit. Thelarge U2AF subunit recognises the intronic polypyrimidine tract.sequence located adjacent to the 3 splice site that serves as an importantsignal for both constitutive and regulated pre-mRNA splicing. The smallsubunit interacts with the 3 splice site dinucleotide AG and is essentialfor regulated splicing. The subunits shuttle continuously between thenucleus and the cytoplasm via a mechanism that involves carrier receptors and is independent of binding to mRNA. Both subunits contain an arginine/serine-rich (RS) domain.hich acts as a nuclear localisation signal.Furthermore.he presence of an RS domain on either subunit is sufficient to trigger the nucleocytoplasmic import of the heterodimeric complex.The human form of the U2 auxiliary factor small subunit.U2AF35.ontainsa degenerate RNA recognition motif (RRM) and a C-terminal RS domain. Themurine form has been shown to be genomically imprinted with monoallelicexpression from the paternal allele. However.his is not the case inhumans .
  IPR009145:U2 auxiliary factor small subunit
SequencesProtein: U2AF1_HUMAN (239 aa)
mRNA: NM_006758
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 98 residues, 43386135-43386428Exon2: 33 residues, 43387649-43387742Exon3: 46 residues, 43387833-43387967Exon4: 35 residues, 43388616-43388715Exon5: 18 residues, 43388872-43388922Exon6: 24 residues, 43393631-43393698Exon7: 31 residues, 43397493-43397581Exon8: 44 residues, 43400629-43400757Exon9: 2 residues, -Jump to U2AF1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4553 43386135-43400757 ~-15K 23977(U2AF1)(-)Loci: 3290 43186446-43202841 ~-16K 23968(NDUFV3)(+)Link out to UCSC