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0TYDP1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTDP1
DescriptionTyrosyl-dna phosphodiesterase 1 (ec 3.1.4.-) (tyr-dna phosphodiesterase 1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (NAS)
0017005 tyrosyl-DNA phosophodiesterase activity (NAS)
0006281 DNA repair (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Covalent intermediates between topoisomerase I and DNA can become dead-end complexes that lead to cell death. Tyrosyl-DNA phosphodiesterase can hydrolyse the bond between topoisomerase I and DNA .
  IPR010347:Tyrosyl-DNA phosphodiesterase
IPR010347:Tyr-DNA_phospho 
Evalue:-141.88606262207 
Location:159-582
SequencesProtein: TYDP1_HUMAN (608 aa)
mRNA: BC006083 BC107877 NM_018319
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
?
sdb:0265 cAMP mediated STP  (Evidence:keywords)
KO assignmentK01113
  Level 3 annotation:
    phosphodiesterase/alkaline phosphatase D
  Level 2 annotation:
    Inorganic ion transport and metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 24 residues, 89491998-89492067Exon2: 76 residues, 89492674-89492897Exon3: 190 residues, 89499204-89499770Exon4: 16 residues, 89502243-89502287Exon5: 20 residues, 89503463-89503519Exon6: 34 residues, 89507271-89507368Exon7: 13 residues, 89511877-89511912Exon8: 33 residues, 89516636-89516729Exon9: 58 residues, 89520612-89520780Exon10: 28 residues, 89521228-89521307Exon11: 64 residues, 89525001-89525187Exon12: 18 residues, 89525813-89525862Exon13: 24 residues, 89528013-89528080Exon14: 38 residues, 89529472-89529580Exon15: 36 residues, 89555412-89555515Exon16: 17 residues, 89559128-89559174Exon17: 38 residues, 89569202-89569311Exon18: 91 residues, 89579166-89579435Exon19: 2 residues, -Jump to TYDP1_HUMANExon1: 24 residues, 89491998-89492067Exon2: 76 residues, 89492674-89492897Exon3: 190 residues, 89499204-89499770Exon4: 16 residues, 89502243-89502287Exon5: 20 residues, 89503463-89503519Exon6: 34 residues, 89507271-89507368Exon7: 13 residues, 89511877-89511912Exon8: 33 residues, 89516636-89516729Exon9: 58 residues, 89520612-89520780Exon10: 28 residues, 89521228-89521307Exon11: 64 residues, 89525001-89525187Exon12: 18 residues, 89525813-89525862Exon13: 24 residues, 89528013-89528080Exon14: 38 residues, 89529472-89529580Exon15: 36 residues, 89555412-89555515Exon16: 38 residues, 89569202-89569311Exon17: 566 residues, 89579166-89580859Exon18: 2 residues, -Jump to TYDP1_HUMANExon1: 79 residues, 89492661-89492897Exon2: 190 residues, 89499204-89499770Exon3: 16 residues, 89502243-89502287Exon4: 20 residues, 89503463-89503519Exon5: 34 residues, 89507271-89507368Exon6: 13 residues, 89511877-89511912Exon7: 33 residues, 89516636-89516729Exon8: 56 residues, 89519210-89519373Exon9: 58 residues, 89520612-89520780Exon10: 28 residues, 89521228-89521307Exon11: 21 residues, 89523082-89523139Exon12: 64 residues, 89525001-89525187Exon13: 18 residues, 89525813-89525862Exon14: 24 residues, 89528013-89528080Exon15: 38 residues, 89529472-89529580Exon16: 36 residues, 89555412-89555515Exon17: 38 residues, 89569202-89569311Exon18: 92 residues, 89579166-89579436Exon19: 2 residues, -Jump to TYDP1_HUMAN  
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Loci Cluster (Details)Loci: 2856 89491998-89580859 ~-89K 11593(TDP1)(+)Loci: 2857 89933128-89941704 ~-9K 11603(CALM1)(+)Loci: 4144 89331265-89490568 ~-159K 11590(-)Link out to UCSC