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0TYB10_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionThymosin beta-10.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Thymosin beta-4 is a small polypeptide whose exact physiological role is notyet known . It was firstisolated as a thymic hormone that induces terminal deoxynucleotidyltransferase. It isfound in high quantity in thymus and spleen but is widely distributed in many tissues.It has also been shown to bind to actin monomers and thus to inhibit actinpolymerization .A number of peptides closely related to thymosin beta-4 belong to this family. Theyinclude.hymosin beta-9 (and beta-8) in Bos taurus and Sus scrofa (pig).hymosin beta-10 in man and Rattus norvegicus (rat).hymosin beta-11 and beta-12 in Oncorhynchus mykiss (Rainbow Trout) and human Nb thymosinbeta.
  IPR001152:Thymosin beta-4
SequencesProtein: TYB10_HUMAN (43 aa)
mRNA: M92381 NM_021103
Local Annotation
Synapse Ontology
actin exists in two states within the cell: as polymerized two-stranded helical filaments (F-actin) or as monomers (Gactin), which provide the building blocks for filament assembly.
sdb:0283 G-actin  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 27 residues, 84986273-84986353Exon2: 40 residues, 84986637-84986752Exon3: 97 residues, 84987023-84987310Exon4: 2 residues, -Jump to TYB10_HUMANExon1: 39 residues, 84986636-84986752Exon2: 96 residues, 84987023-84987305Exon3: 2 residues, -Jump to TYB10_HUMAN  
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Loci Cluster (Details)Loci: 3174 84986273-84987310 ~-1K 20748(TMSB10)(+)Loci: 4455 85398657-85408885 ~-10K 20753(TGOLN2)(-)Loci: 3175 85658227-85662664 ~-4K 20772(VAMP8)(+)Loci: 3176 85665041-85674022 ~-9K 20773(VAMP5)(+)Loci: 4454 84504186-84539896 ~-36K 20743(SUCLG1)(-)Link out to UCSC