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0TY3H_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTH
DescriptionTyrosine 3-monooxygenase (ec 1.14.16.2) (tyrosine 3-hydroxylase) (th).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004511 tyrosine 3-monooxygenase activity (TAS)
0006584 catecholamine metabolism (TAS)
0009653 morphogenesis (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Phenylalanine.yrosine and tryptophan hydroxylases constitute a family of tetrahydrobiopterin-dependent aromatic amino acid hydroxylases.ll of which are rate-limiting catalysts for important metabolic pathways . The proteins are structurally and functionally related.ach containing iron.nd catalysing ring hydroxylation of aromatic amino acids.sing tetra-hydrobiopterin (BH4) as a substrate. All are regulated by phosphorylation at serines in their N-termini. It has been suggested that the proteins each contain a conserved C-terminal catalytic (C) domain and an unrelated N-terminal regulatory (R) domain. It is possible that the R domains arose from genes that were recruited from different sources to combine with the common gene for the catalytic core. Thus.y combining with the same C domain.he proteins acquiredthe unique regulatory properties of the separate R domains.A variety of enzymes belong to this family that includes.henylalanine-4-hydroxylase from Chromobacterium violaceum where it is copper-dependent; it is iron-dependent in Pseudomonas aeruginosa.henylalanine-4-hydroxylase catalyzes the conversion of phenylalanine to tyrosine. In humans.eficiencies are the cause of phenylketonuria.he most common inborn error of amino acid metabolism .ryptophan 5-hydroxylase catalyzes the rate-limiting step in serotonin biosynthesis: the conversion of tryptophan to 3-hydroxy-anthranilate and tyrosine 3-hydroxylase catalyzes the rate limiting step in catecholamine biosynthesis: the conversion of tyrosine to 3.-dihydroxy-L-phenylalanine.
  IPR001273:Aromatic amino acid hydroxylase
Tyrosine 3-monooxygenase ().s a member of the family of tetrameric.iopterin-dependent aromatic amino acid hydroxylases found in metazoans. It is closely related to tetrameric phenylalanine-4-hydroxylase and tryptophan 5-monooxygenase.nd more distantly related to the monomeric phenylalanine-4-hydroxylase found in some Gram-negative bacteria. It catalyses the first step in catecholamine biosynthesis. L-tyrosine + tetrahydropteridine + O2 = 3.-dihydroxy-L-phenylalanine + dihydropteridine + H2O.
  IPR005962:Tyrosine 3-monooxygenase
IPR001273:Biopterin_H 
Evalue:-286.886047363281 
Location:195-526
SequencesProtein: TY3H_HUMAN (528 aa)
mRNA: NM_199292 NM_199293
Local Annotation
Synapse Ontology
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords)
KO assignmentK00501
  Level 3 annotation:
    tyrosine 3-monooxygenase
  Level 2 annotation:
    Tyrosine metabolism
    Parkinson's disease
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 155 residues, 2141735-2142198Exon2: 46 residues, 2143037-2143171Exon3: 34 residues, 2143473-2143569Exon4: 21 residues, 2143807-2143864Exon5: 25 residues, 2144285-2144355Exon6: 47 residues, 2144438-2144574Exon7: 50 residues, 2144692-2144838Exon8: 19 residues, 2145240-2145291Exon9: 24 residues, 2145671-2145739Exon10: 31 residues, 2145896-2145985Exon11: 60 residues, 2146296-2146471Exon12: 76 residues, 2147455-2147677Exon13: 29 residues, 2148495-2148576Exon14: 39 residues, 2149490-2149601Exon15: 2 residues, -Jump to TY3H_HUMANExon1: 155 residues, 2141735-2142198Exon2: 46 residues, 2143037-2143171Exon3: 34 residues, 2143473-2143569Exon4: 21 residues, 2143807-2143864Exon5: 25 residues, 2144285-2144355Exon6: 47 residues, 2144438-2144574Exon7: 50 residues, 2144692-2144838Exon8: 19 residues, 2145240-2145291Exon9: 24 residues, 2145671-2145739Exon10: 31 residues, 2145896-2145985Exon11: 60 residues, 2146296-2146471Exon12: 76 residues, 2147455-2147677Exon13: 29 residues, 2148495-2148576Exon14: 36 residues, 2149502-2149605Exon15: 2 residues, -Jump to TY3H_HUMAN  
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Loci Cluster (Details)Loci: 3930 2141735-2149605 ~-8K 6153(TH)(-)Loci: 2645 2355122-2375225 ~-20K 6164(CD81)(+)Loci: 2646 2422796-2826915 ~-404K 6167(KCNQ1)(+)Loci: 2644 1812281-1815326 ~-3K 6136(SYT8)(+)Link out to UCSC