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0TXTP_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSLC25A1
DescriptionTricarboxylate transport protein, mitochondrial precursor (citrate transport protein) (ctp) (tricarboxylate carrier protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005743 mitochondrial inner membrane (TAS)
0015137 citrate transporter activity (TAS)
0006843 mitochondrial citrate transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
A variety of substrate carrier proteins that are involved in energy transfer are found in the inner mitochondrial membrane or integral to the membrane of other eukaryotic organelles such as the peroxisome . Such proteins include: ADP.TP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrier protein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Graves disease carrier protein; yeast mitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein; and many others. Structurally.hese proteins can consist of up to three tandem repeats of a domain of approximately 100 residues.ach domain containing two transmembrane regions.
  IPR001993:Mitochondrial substrate carrier
A variety of substrate carrier proteins that are involved in energy transferare found in the inner mitochondrial membrane . Such proteins include:ADP/ATP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrierprotein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Graves disease carrier protein; yeast mitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein;and many others.Sequence analysis of selected members of the carrier protein family hassuggested the presence of six transmembrane (TM) domains.ith varying degrees of sequence conservation and hydrophilicity . The TM regions.nd adjacent hydrophilic loops.re more highly conserved than otherregions of the proteins . All members of the family appear to consistof a tripartite structure.ach of the repeated segments being about 100 residuesin length . Each repeat contains two TM domains.he first being morehydrophobic.ith conserved glycyl and prolyl residues. Five of the six TMdomains are followed by the conserved sequence (D/E)-Hy(K/R) {where - denotesany residue.nd Hy is a hydrophobic position} .
  IPR002067:Mitochondrial carrier protein
A variety of substrate carrier proteins that are involved in energy transferare found in the inner mitochondrial membrane . Such proteins include:ADP.TP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrierprotein; phosphate carrier protein; tricarboxylate transport protein (orcitrate transport protein); Graves disease carrier protein; yeastmitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein;and many others.Sequence analysis of selected members of the carrier protein family hassuggested the presence of six transmembrane (TM) domains.ith varyingdegrees of sequence conservation and hydrophilicity . The TM regions.nd adjacent hydrophilic loops.re more highly conserved than otherregions of the proteins . All members of the family appear to consistof a tripartite structure.ach of the repeated segments being ~100 residuesin length . Each repeat contains two TM domains.he first being morehydrophobic.ith conserved glycyl and prolyl residues. Five of the six TMdomains are followed by the conserved sequence (D/E)-Hy(K/R){where - denotesany residue.nd Hy is a hydrophobic position} .Mitochondrial ADP/ATP translocase.n abundant component of the innermembrane.arries ATP from the matrix into the inter-membrane space andtransports ADP back . The protein is an integral membrane protein thatfunctions as a homodimer.
  IPR002113:Adenine nucleotide translocator 1
IPR001993:Mito_carr 
Evalue:-29.6777801513672 
Location:24-116IPR001993:Mito_carr 
Evalue:-27.4202156066895 
Location:219-308IPR001993:Mito_carr 
Evalue:-23.0132274627686 
Location:120-213
SequencesProtein: TXTP_HUMAN (311 aa)
mRNA: NM_005984
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK03454
  Level 3 annotation:
    mitochondrial carrier protein, MC family
  Level 2 annotation:
    Other ion-coupled transporters
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 222 residues, 17543094-17543757Exon2: 26 residues, 17543933-17544007Exon3: 40 residues, 17544090-17544206Exon4: 37 residues, 17544358-17544463Exon5: 30 residues, 17544632-17544717Exon6: 48 residues, 17545239-17545378Exon7: 35 residues, 17545454-17545554Exon8: 38 residues, 17545645-17545753Exon9: 66 residues, 17546092-17546285Exon10: 2 residues, -Jump to TXTP_HUMAN  
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Loci Cluster (Details)Loci: 4555 16596905-16637258 ~-40K 24143(BID)(-)Loci: 3295 16973558-16994498 ~-21K 24153(TUBA8)(+)Loci: 4556 17280294-17304066 ~-24K 24158(PRODH)(-)Loci: 4557 17543094-17546285 ~-3K 24164(SLC25A1)(-)Loci: 4558 17698223-17799219 ~-101K 24167(HIRA)(-)Loci: 3296 18081986-18090842 ~-9K 24176(SEPT5)(+)Loci: 4559 18243045-18309515 ~-66K 24188(TXNRD2)(-)Loci: 3297 18309308-18336528 ~-27K 24191(COMT)(+)Loci: 3294 16423182-16453647 ~-30K 24138(SLC25A18)(+)Link out to UCSC