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0TWF1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePTK9
DescriptionTwinfilin-1 (a6 protein) (protein tyrosine kinase 9).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0015629 actin cytoskeleton (ISS)
0004713 protein-tyrosine kinase activity (IDA)
0006468 protein amino acid phosphorylation (IDA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The ADF/cofilins are a family of actin-binding proteins expressed in all eukaryotic cells so far examined. Members of this family remodel the actin cytoskeleton.or example during cytokinesis.hen the actin-rich contractile ring shrinks as it contracts through the interaction of ADF/cofilins with both monomeric and filamentous actin. ADF/cofilins sever actin filaments (F-actin) and/or bind to actin monomers.r G-actin.hus preventing actin-polymerization by sequestering the monomers. The ADF/cofilins are formed by a single folded domain.he ADF homology domain.hich is also found in other actin-binding protein families and is the most conserved region of these proteins consisting of a twenty amino-acid segment that ends some 30 residues from their C-terminal extremity . The main actin-binding structure being a long alpha-helix. Plants and animals have multiple ADF/cofilin genes.elonging in vertebrates to two types.DF and cofilins. Other eukaryotes (such as yeast.canthamoeba and slime moulds) have a single ADF/cofilin gene. The following proteins are evolutionary related and belong to a family of low molecular weight (137 to 166 residues) actin-depolymerizing proteins .Cofilin from vertebrates.lime mold and yeast. Cofilin binds to F-actin and acts as a pH-dependent actin-depolymerizing protein.Destrin from vertebrates. Destrin binds to G-actin in a pH-independent manner and prevents polymerization.Caenorhabditis elegans unc-60.Acanthamoeba castellanii actophorin.Plants actin depolymerizing factor (ADF).
  IPR002108:Actin-binding, cofilin/tropomyosin type
IPR002108:ADF 
Evalue:-37.6197887582884 
Location:29-157IPR002108:ADF 
Evalue:-30.5528419686578 
Location:202-331
SequencesProtein: TWF1_HUMAN (368 aa)
mRNA: BC022344 NM_002822
Local Annotation
Synapse Ontology
actin exists in two states within the cell: as polymerized two-stranded helical filaments (F-actin) or as monomers (Gactin), which provide the building blocks for filament assembly.
sdb:0283 G-actin  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 678 residues, 42473794-42475825Exon2: 42 residues, 42477045-42477167Exon3: 52 residues, 42477371-42477522Exon4: 44 residues, 42477777-42477903Exon5: 37 residues, 42479467-42479572Exon6: 34 residues, 42480504-42480600Exon7: 61 residues, 42482355-42482534Exon8: 28 residues, 42484564-42484642Exon9: 20 residues, 42485900-42485955Exon10: 24 residues, 42486290-42486357Exon11: 2 residues, -Jump to TWF1_HUMANExon1: 678 residues, 42473794-42475825Exon2: 42 residues, 42477045-42477167Exon3: 52 residues, 42477371-42477522Exon4: 44 residues, 42477777-42477903Exon5: 37 residues, 42479467-42479572Exon6: 34 residues, 42480504-42480600Exon7: 61 residues, 42482355-42482534Exon8: 28 residues, 42484564-42484642Exon9: 53 residues, 42486290-42486445Exon10: 2 residues, -Jump to TWF1_HUMAN  
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