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0TTLL1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTTLL1
DescriptionTubulin tyrosine ligase-like protein 1.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Tubulins and microtubules are subjected to several post-translational modifications of which the reversible detyrosination/tyrosination of the carboxy-terminal end of most alpha-tubulins has been extensively analysed. This modification cycle involves a specific carboxypeptidase and the activity of the tubulin-tyrosine ligase (TTL) . Tubulin-tyrosine ligase (TTL) catalyses the ATP-dependent post-translational addition of a tyrosine to the carboxy terminal end of detyrosinated alpha-tubulin. The true physiological function of TTL has so far not been established. In normally cycling cells.he tyrosinated form of tubulin predominates. However.n breast cancer cells.he detyrosinated form frequently predominates.ith a correlation to tumour aggressiveness . 3-nitrotyrosine has been shown to be incorporated.y TTL.nto the carboxy terminal end of detyrosinated alpha-tubulin. This reaction is not reversible by the carboxypeptidase enzyme. Cells cultured in 3-nitrotyrosine rich medium showed evidence of altered microtubule structure and function.ncluding altered cell morphology.pithelial barrier dysfunction.nd apoptosis .
  IPR004344:Tubulin-tyrosine ligase
The ATP-grasp fold is one of several distinct ATP-binding folds.nd is found in enzymes that catalyze the formation of amide bonds.atalyzing the ATP-dependent ligation of a carboxylate-containing molecule to an amino or thiol group-containing molecule . This fold is found in many different enzyme families.ncluding various peptide synthetases.iotin carboxylase.ynapsin.uccinyl-CoA synthetase.yruvate phosphate dikinase.nd glutathione synthetase.mongst others . These enzymes contribute predominantly to macromolecular synthesis.sing ATP-hydrolysis to activate their substrates. The ATP-grasp fold shares functional and structural similarities with the PIPK (phosphatidylinositol phosphate kinase) and protein kinase superfamilies. The ATP-grasp domain consists of two subdomains with different alpha+beta folds.hich grasp the ATP molecule between them. Each subdomain provides a variable loop that forms part of the active site.ith regions from other domains also contributing to the active site.ven though these other domains are not conserved between the various ATP-grasp enzymes . This entry represents subdomain 2 found at the C-terminal end of the ATP-grasp domain (the N-terminal subdomain is represented by ().
  IPR013816:ATP-grasp fold, subdomain 2
IPR004344:TTL 
Evalue:-153.585021972656 
Location:48-364
SequencesProtein: TTLL1_HUMAN (423 aa)
mRNA: AF173935 NM_001008572 NM_012263
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 89 residues, 41765589-41765855Exon2: 56 residues, 41772359-41772523Exon3: 31 residues, 41777750-41777837Exon4: 50 residues, 41785333-41785477Exon5: 38 residues, 41789762-41789871Exon6: 47 residues, 41790139-41790274Exon7: 62 residues, 41794359-41794540Exon8: 71 residues, 41795585-41795794Exon9: 26 residues, 41796120-41796192Exon10: 41 residues, 41801423-41801540Exon11: 30 residues, 41805851-41805936Exon12: 51 residues, 41815226-41815373Exon13: 2 residues, -Jump to TTLL1_HUMANExon1: 89 residues, 41765589-41765855Exon2: 56 residues, 41772359-41772523Exon3: 31 residues, 41777750-41777837Exon4: 50 residues, 41785333-41785477Exon5: 38 residues, 41789762-41789871Exon6: 47 residues, 41790139-41790274Exon7: 62 residues, 41794359-41794540Exon8: 71 residues, 41795585-41795794Exon9: 41 residues, 41801423-41801540Exon10: 30 residues, 41805851-41805936Exon11: 51 residues, 41815226-41815373Exon12: 2 residues, -Jump to TTLL1_HUMANExon1: 88 residues, 41765594-41765855Exon2: 56 residues, 41772359-41772523Exon3: 31 residues, 41777750-41777837Exon4: 50 residues, 41785333-41785477Exon5: 38 residues, 41789762-41789871Exon6: 47 residues, 41790139-41790274Exon7: 62 residues, 41794359-41794540Exon8: 82 residues, 41795553-41795794Exon9: 26 residues, 41796120-41796192Exon10: 41 residues, 41801423-41801540Exon11: 30 residues, 41805851-41805936Exon12: 22 residues, 41815226-41815288Exon13: 2 residues, -Jump to TTLL1_HUMAN  
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Loci Cluster (Details)Loci: 4575 41595721-41741095 ~-145K 24901(PACSIN2)(-)Loci: 4576 41765589-41815373 ~-50K 24903(TTLL1)(-)Loci: 3322 41877478-41889191 ~-12K 24908(BZRP)(+)Loci: 4574 41344764-41375349 ~-31K 24894(CYB5R3)(-)Link out to UCSC