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0TRUA_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePUS1
Descriptiontrna pseudouridine synthase a (ec 5.4.99.12) (trna-uridine isomerase i) (trna pseudouridylate synthase i).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (NAS)
0004730 pseudouridylate synthase activity (NAS)
0008033 tRNA processing (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Transfer RNA-pseudouridine synthetase contains one atom of zinc essential for its native conformation and tRNA recognition and has a strictly conserved aspartic acid that is likely to be involved in catalysis. It is involved in the formation of pseudouridine at positions 38.9 and 40 in the anticodon stem and loop of transfer-RNAs. Pseudouridine is the most abundant modified nucleoside found in all cellular RNAs.
  IPR001406:tRNA pseudouridine synthase
IPR001406:PseudoU_synth_1 
Evalue:-18.8860569000244 
Location:53-168IPR001406:PseudoU_synth_1 
Evalue:-11.1191864013672 
Location:169-311
SequencesProtein: TRUA_HUMAN (399 aa)
mRNA: NM_001002019 NM_025215
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK06173
  Level 3 annotation:
    tRNA pseudouridine synthase A
  Level 2 annotation:
    Pyrimidine metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 185 residues, 130979741-130980294Exon2: 78 residues, 130980404-130980633Exon3: 48 residues, 130982672-130982810Exon4: 36 residues, 130989670-130989773Exon5: 232 residues, 130991789-130992481Exon6: 108 residues, 130994036-130994355Exon7: 2 residues, -Jump to TRUA_HUMANExon1: 54 residues, 130979741-130979902Exon2: 78 residues, 130980404-130980633Exon3: 48 residues, 130982672-130982810Exon4: 36 residues, 130989670-130989773Exon5: 232 residues, 130991789-130992481Exon6: 108 residues, 130994036-130994355Exon7: 2 residues, -Jump to TRUA_HUMAN  
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Loci Cluster (Details)Loci: 2803 130979741-130994355 ~-15K 10034(PUS1)(+)Loci: 2804 131000460-131130957 ~-130K 10036(EP400)(+)Loci: 2802 130945231-130973649 ~-28K 10032(ULK1)(+)Link out to UCSC