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0TRPM2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTRPM2
DescriptionTransient receptor potential cation channel subfamily m member 2 (ec 3.6.1.13) (long transient receptor potential channel 2) (ltrpc2) (ltrpc-2) (transient receptor potential channel 7) (trpc7) (estrogen responsive element associated gene protein 1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005262 calcium channel activity (TAS)
0006816 calcium ion transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This group of proteins is found in sodium.otassium.nd calcium ion channels proteins. The proteins have 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some Na channels proteins the domain is repeated four times.hereas in others (e.g. K channels) the protein forms a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not included in the Pfam family due to it lacking the first four helices.
  IPR005821:Ion transport
MutT is a small bacterial protein (~12-15Kd) involved in the GO system responsible for removing an oxidatively damaged form of guanine (8-hydroxy- guanine or 7.-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with near equal efficiency.eading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate.ith the concomitant release of pyrophosphate. A short conserved N-terminal region of mutT (designated the MutT domain) is also found in a variety of other prokaryotic.iral and eukaryotic proteins . The generic name NUDIX hydrolases (NUcleoside DIphosphate linked to some other moiety X) has been coined for this domain family . The family can be divided into a number of subgroups.f which MutT anti- mutagenic activity represents only one type; most of the rest hydrolyse diverse nucleoside diphosphate derivatives (including ADP-ribose.DP- mannose.DP-glucose.ADH.DP-sugars.NTP and NTP).
  IPR000086:NUDIX hydrolase
Transient receptor potential (Trp) and related proteins are thought to beCa2+ ion channel subunits that mediate capacitative Ca2+ entry in responseto a range of external and internal cell stimuli. Such Ca2+ entry is thoughtto be an essential component of cellular responses to many hormones andgrowth factors.nd acts to replenish intracellular Ca2+ stores that havebeen emptied through the action of inositol triphosphate (IP3) and otheragents. In non-excitable cells..e. those that lack voltage-gated Ca2+channels.uch as hepatocytes.his mode of Ca2+ entry is thought to be animportant step in generating the oscillations of intracellular Ca2+concentration that characterise their response to stimulatory agents .Studies on the visual transduction system in Drosophila led to the molecularcloning of Trp and the cDNA of a related protein.rp-like.hich showsimilarity to voltage gated Ca2+ channels in the regions known as S3 throughS6.ncluding the S5-S6 linker that forms the ion-selective channel pore .This provided evidence that Trp and/or related proteins might form mammaliancapacitative Ca2+ entry channels. They have varying lengths (usually 800-1000amino acid residues).nd hydropathy analyses suggest that they have six ormore transmebrane (TM) regions.lanked by cytosolic N- and C-termini.
  IPR002153:Transient receptor potential protein
IPR005821:Ion_trans 
Evalue:-15.2757244110107 
Location:830-1048IPR000086:NUDIX_hydrolase 
Evalue:0 
Location:1355-1396IPR002153:TRNSRECEPTRP 
Evalue:0 
Location:1052-1065IPR002153:TRNSRECEPTRP 
Evalue:0 
Location:1079-1092IPR000086:NUDIX 
Evalue:0 
Location:0-0
SequencesProtein: TRPM2_HUMAN (1503 aa)
mRNA: NM_003307
Local Annotation
Synapse Ontology
Na channel plays an important role in the course of action potential.
sdb:0287 Na channel  (Evidence:keywords)
KO assignmentK04977
  Level 3 annotation:
    transient receptor potential cation channel, subfamily M, member 2
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 89 residues, 44597911-44598176Exon2: 31 residues, 44598958-44599047Exon3: 58 residues, 44608424-44608593Exon4: 62 residues, 44611064-44611245Exon5: 57 residues, 44613487-44613654Exon6: 62 residues, 44620143-44620324Exon7: 22 residues, 44622022-44622084Exon8: 69 residues, 44623307-44623508Exon9: 36 residues, 44627028-44627131Exon10: 42 residues, 44635214-44635336Exon11: 120 residues, 44635582-44635936Exon12: 48 residues, 44639724-44639862Exon13: 45 residues, 44642057-44642187Exon14: 50 residues, 44643606-44643752Exon15: 39 residues, 44644569-44644682Exon16: 74 residues, 44645991-44646208Exon17: 41 residues, 44649452-44649571Exon18: 46 residues, 44650215-44650348Exon19: 59 residues, 44650904-44651076Exon20: 63 residues, 44658201-44658385Exon21: 62 residues, 44662237-44662419Exon22: 46 residues, 44662733-44662866Exon23: 31 residues, 44667955-44668043Exon24: 31 residues, 44669162-44669250Exon25: 54 residues, 44669980-44670138Exon26: 27 residues, 44670970-44671047Exon27: 36 residues, 44671320-44671422Exon28: 31 residues, 44679441-44679528Exon29: 37 residues, 44681372-44681478Exon30: 36 residues, 44683377-44683479Exon31: 41 residues, 44685099-44685216Exon32: 465 residues, 44686002-44687392Exon33: 2 residues, -Jump to TRPM2_HUMAN  
Loci Cluster (Details)Loci: 3292 44597911-44687392 ~-89K 24018(TRPM2)(+)Loci: 3291 44351635-44375490 ~-24K 24002(PWP2H)(+)Link out to UCSC