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0TRNT1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTRNT1
Descriptiontrna-nucleotidyltransferase 1, mitochondrial precursor (ec 2.7.7.25) (mitochondrial trna nucleotidyl transferase, cca-adding) (mt trna adenylyltransferase) (mt trna cca-pyrophosphorylase) (mt trna cca- diphosphorylase) (mt cca-adding enzyme).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (IDA)
0005524 ATP binding (TAS)
0004810 tRNA adenylyltransferase activity (IDA)
0000049 tRNA binding (IDA)
0006626 protein-mitochondrial targeting (TAS)
0042780 tRNA 3'-processing (IDA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This group includes nucleic acid independent RNA polymerases.uch as polynucleotide adenylyltransferase ().hich adds the poly (A) tail to mRNA. This group also includes the tRNA nucleotidyltransferase that adds the CCA to the 3 of the tRNA .
  IPR002646:Polynucleotide adenylyltransferase region
This family includes poly(A) polymerases and tRNA nucleotidyltransferases. Poly(A) polymerases are RNA polymerases that add multiple AMPs (also referred to as poly(A) tails) to the 3 end of messenger RNAs. These poly (A) tails promote the degradation of the attached mRNAs by 3-5 exonucleases. tRNA nuceotidyltransferases are responsible for the synthesis or repair of the 3 terminal CCA sequence of tRNA molecules. They are coded by essential genes in almost all organisms and add the three ribonucleotides C..nd A to the 3 end of tRNAs in sequential order. Some members of this family carry an auxiliary HD domain that are metal dependent phosphohydrolases.For additional information please see .
  IPR012222:Poly-A polymerase/tRNA nucleotidyltransferase
IPR002646:PolyA_pol 
Evalue:-46.0604820251465 
Location:110-276
SequencesProtein: TRNT1_HUMAN (434 aa)
mRNA: BC012537 NM_016000
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00974
  Level 3 annotation:
    tRNA nucleotidyltransferase (CCA-adding enzyme)
  Level 2 annotation:
    Other translation proteins
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 8 residues, 3143652-3143674Exon2: 60 residues, 3145697-3145872Exon3: 66 residues, 3153943-3154137Exon4: 48 residues, 3157193-3157332Exon5: 44 residues, 3161267-3161394Exon6: 66 residues, 3163113-3163307Exon7: 86 residues, 3164133-3164387Exon8: 96 residues, 3164589-3164871Exon9: 48 residues, 3165777-3165917Exon10: 103 residues, 3167223-3167528Exon11: 2 residues, -Jump to TRNT1_HUMANExon1: 8 residues, 3143652-3143674Exon2: 60 residues, 3145697-3145872Exon3: 66 residues, 3153943-3154137Exon4: 48 residues, 3157193-3157332Exon5: 44 residues, 3161267-3161394Exon6: 66 residues, 3163113-3163307Exon7: 86 residues, 3164133-3164387Exon8: 96 residues, 3164589-3164871Exon9: 48 residues, 3165777-3165917Exon10: 103 residues, 3167223-3167528Exon11: 2 residues, -Jump to TRNT1_HUMAN  
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