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0TRIB3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTRIB3
DescriptionTribbles homolog 3 (trb-3) (neuronal cell death inducible putative kinase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (ISS)
0005515 protein binding (IPI)
0019901 protein kinase binding (IPI)
0003714 transcription corepressor activity (ISS)
0000187 activation of MAPK activity (IDA)
0006915 apoptosis (ISS)
0006469 negative regulation of protein kinase activity (ISS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR000719:Pkinase 
Evalue:-18.1487407684326 
Location:223-315
SequencesProtein: TRIB3_HUMAN (358 aa)
mRNA: NM_021158
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 169 residues, 309307-309813Exon2: 99 residues, 316654-316945Exon3: 99 residues, 319930-320223Exon4: 455 residues, 324841-326201Exon5: 2 residues, -Jump to TRIB3_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3226 336755-359608 ~-23K 22500(UBCE7IP3)(+)Loci: 4505 411337-472482 ~-61K 22506(CSNK2A1)(-)Loci: 3225 309307-326201 ~-17K 22496(TRIB3)(+)Link out to UCSC