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0TRH_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTRH
DescriptionThyroliberin precursor .
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005625 soluble fraction (TAS)
0008437 thyrotropin-releasing hormone activity (TAS)
0007267 cell-cell signaling (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This family consists of several thyrotropin-releasing hormone (TRH) proteins. Thyrotropin-Releasing Hormone (TRH; pyroGlu-His-Pro-NH2).riginally isolated as a hypothalamic neuropeptide hormone.ost likely acts also as a neuromodulator and/or neurotransmitter in the central nervous system (CNS). This interpretation is supported by the identification of a peptidase localised on the surface of neuronal cells which has been termed TRH-degrading ectoenzyme (TRH-DE) since it selectively inactivates TRH. TRH has been used clinically for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans .
  IPR008857:Thyrotropin-releasing hormone
IPR008857:TRH 
Evalue:-142.154907226562 
Location:4-210
SequencesProtein: TRH_HUMAN (242 aa)
mRNA: NM_007117
Local Annotation
Synapse Ontology
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 35 residues, 131176252-131176356Exon2: 75 residues, 131177341-131177560Exon3: 415 residues, 131178231-131179470Exon4: 2 residues, -Jump to TRH_HUMAN  
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Loci Cluster (Details)Loci: 3375 130081143-130114646 ~-34K 26440(ACAD9)(+)Loci: 4632 130289107-130323309 ~-34K 26447(-)Loci: 4633 130602854-130630184 ~-27K 26461(-)Loci: 4634 130632482-130641542 ~-9K 26462(MBD4)(-)Loci: 4635 130756707-130808351 ~-52K 26476(PLXND1)(-)Loci: 4636 130849326-131081999 ~-233K 26481(TMCC1)(-)Loci: 3376 131176252-131179470 ~-3K 26482(TRH)(+)Loci: 3374 129927668-130016331 ~-89K 26437(RAB7)(+)Link out to UCSC