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0TRFE_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTF
DescriptionSerotransferrin precursor (transferrin) (siderophilin) (beta-1-metal binding globulin).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005576 extracellular region (NAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Transferrins are eukaryotic iron-binding glycoproteins that control thelevel of free iron in biological fluids . The proteins have arisen by duplication of adomain.ach duplicated domain binding one iron atom. Members of the family includeblood serotransferrin (siderophilin); milk lactotransferrin (lactoferrin); egg whiteovotransferrin (conalbumin); and membrane-associated melanotransferrin.Human lactoferrin is a serine peptidase belonging to MEROPS peptidase family S60.lan SR. It is found at high concentrations in all human secretions.here it plays a major role in mucosal defence. Lactoferrin cleaves IgA1 protease at an arginine-rich region defined by amino acids RRSRRSVR and digests Hap at a similar arginine-rich sequence (VRSRRAAR). Ser259 and Lys73 form a catalytic dyad.eminiscent of a number of bacterial serine proteases.
  IPR001156:Peptidase S60, transferrin lactoferrin
IPR001156:Transferrin 
Evalue:-256.552856445312 
Location:25-347IPR001156:TR_FER 
Evalue:-218.795880017344 
Location:361-687
SequencesProtein: TRFE_HUMAN (698 aa)
mRNA: NM_001063
Local Annotation
Synapse Ontology
Microglias, one kind of glias in CNS, are responsible for removing most of the waste and cellular debris from the CNS
sdb:0267 removing metabolic mass  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 32 residues, 134947924-134948017Exon2: 59 residues, 134949945-134950118Exon3: 38 residues, 134955128-134955237Exon4: 61 residues, 134956028-134956205Exon5: 46 residues, 134956896-134957029Exon6: 20 residues, 134957815-134957871Exon7: 61 residues, 134958364-134958543Exon8: 61 residues, 134959302-134959480Exon9: 53 residues, 134960708-134960863Exon10: 33 residues, 134965715-134965809Exon11: 13 residues, 134966408-134966441Exon12: 54 residues, 134967811-134967967Exon13: 47 residues, 134969562-134969698Exon14: 23 residues, 134972041-134972106Exon15: 63 residues, 134976966-134977151Exon16: 65 residues, 134978582-134978772Exon17: 70 residues, 134980119-134980325Exon18: 2 residues, -Jump to TRFE_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4637 135030055-135097350 ~-67K 26534(RAB6B)(-)Loci: 3377 134947924-134980325 ~-32K 26531(TF)(+)Link out to UCSC