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0TRAP1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTRAP1
DescriptionHeat shock protein 75 kda, mitochondrial precursor (hsp 75) (tumor necrosis factor type 1 receptor associated protein) (trap-1) (tnfr- associated protein 1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005164 tumor necrosis factor receptor binding (NAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Prokaryotes and eukaryotes respond to heat shock and other forms of environmental stress by inducing synthesis of heat-shock proteins (hsp) . The 90 kDa heat shock protein.sp90.s one of the most abundant proteins in eukaryotic cells.omprising 12% of cellular proteins under non-stress conditions . Its contribution to various cellular processes including signal transduction.rotein folding.rotein degradation and morphological evolution has been extensively studied . The full functional activity of Hsp90 is gained in concert with other co-chaperones.laying an important role in the folding of newly synthesised proteins and stabilisation and refolding of denatured proteins after stress. Apart from its co-chaperones.sp90 binds to an array of client proteins.here the co-chaperone requirement varies and depends on the actual client. The sequences of hsp90s show a distinctive domain structure.ith a highly-conserved N-terminal domain separated from a conserved.cidic C-terminal domain by a highly-acidic.lexible linker region.
  IPR001404:Heat shock protein Hsp90
This domain is found in several ATP-binding proteins for example: histidine kinase.NA gyrase B.opoisomerases .eat shock protein HSP90 .hytochrome-like ATPases and DNA mismatch repair proteins.
  IPR003594:ATP-binding region, ATPase-like
Potassium channels are the most diverse group of the ion channel family. They are important in shaping the action potential.nd in neuronal excitability and plasticity . The potassium channel family iscomposed of several functionally distinct isoforms.hich can be broadlyseparated into 2 groups : the practically non-inactivating delayed group and the rapidly inactivating transient group.These are all highly similar proteins.ith only small amino acidchanges causing the diversity of the voltage-dependent gating mechanism.hannel conductance and toxin binding properties. Each type of K+ channel is activated by different signals and conditions depending on their type of regulation: some open in response to depolarisation of the plasma membrane; others in response to hyperpolarisation or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter.ogether with intracellular kinases; and others are regulated by GTP-binding proteins orother second messengers . In eukaryotic cells.+ channelsare involved in neural signalling and generation of the cardiac rhythm.ct as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes . In prokaryotic cells.hey play a role in themaintenance of ionic homeostasis . All K+ channels discovered so far possess a core of alpha subunits.ach comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG).hich hasbeen termed the K+ selectivity sequence.In families that contain one P-domain.our subunits assemble to form a selective pathway for K+ across the membrane.However.t remains unclear how the 2 P-domain subunits assemble to form a selective pore. The functional diversity of these families can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+ channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains. The six TM domain superfamily can be further subdivided into conserved gene families: the voltage-gated (Kv) channels; the KCNQ channels (originally known as KvLQT channels); the EAG-like K+ channels; and three types of calcium (Ca)-activated K+ channels (BK.K and SK). The 2TM domain family comprises inward-rectifying K+ channels. In addition.here are K+ channel alpha-subunits that possess two P-domains. These are usually highly regulated K+ selective leak channels. The Kv family can be divided into 4 subfamilies on the basis of sequence similarity and function: Shaker (Kv1).hab (Kv2).haw (Kv3) and Shal (Kv4). All consist of pore-forming alpha subunits that associate with different types of beta subunit. Each alpha subunit comprises six hydrophobic TM domains with a P-domain between the fifth and sixth.hich partially resides in the membrane. The fourth TM domain has positively charged residues at every third residue and acts as a voltage sensor.hich triggers the conformational change that opens the channel pore in response to a displacement in membrane potential .The first Shal (Kv4) sequence was found in Drosophila melanogaster. Several vertebrate K+ channels with similar amino acid sequences were subsequently found and.ogether with the Drosophila melanogaster Shal channel.ow constitute the Shal (Kv4) family. These channels support outward K+-selective currents and are inhibited by free fatty acids . The Shal family can be further divided into 3 families.esignated Kv4.1.v4.2 and Kv4.3.
  IPR003975:Shal voltage-gated K+ channel
IPR001404:HSP90 
Evalue:-19.8860569000244 
Location:464-611IPR003594:HATPase_c 
Evalue:-12.187087059021 
Location:108-260IPR001404:HSP90 
Evalue:-0.60206001996994 
Location:641-656IPR001404:HEATSHOCK90 
Evalue:0 
Location:86-106IPR001404:HEATSHOCK90 
Evalue:0 
Location:267-285IPR001404:HSP90 
Evalue:0 
Location:0-0
SequencesProtein: TRAP1_HUMAN (704 aa)
mRNA: NM_016292
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 65 residues, 3648039-3648232Exon2: 26 residues, 3648794-3648867Exon3: 50 residues, 3651988-3652134Exon4: 30 residues, 3652883-3652969Exon5: 48 residues, 3653425-3653564Exon6: 64 residues, 3654275-3654461Exon7: 51 residues, 3655972-3656120Exon8: 25 residues, 3661723-3661793Exon9: 42 residues, 3662701-3662822Exon10: 54 residues, 3664340-3664496Exon11: 26 residues, 3665325-3665399Exon12: 38 residues, 3666037-3666147Exon13: 55 residues, 3667499-3667660Exon14: 26 residues, 3669720-3669792Exon15: 49 residues, 3675997-3676138Exon16: 29 residues, 3679056-3679139Exon17: 55 residues, 3680828-3680987Exon18: 32 residues, 3707422-3707514Exon19: 2 residues, -Jump to TRAP1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2919 3036682-3050723 ~-14K 13385(MMP25)(+)Loci: 4203 3232028-3246628 ~-15K 13403(MEFV)(-)Loci: 2920 3273487-3281456 ~-8K 13405(ZNF263)(+)Loci: 4204 3571183-3601586 ~-30K 13423(BTBD12)(-)Loci: 4205 3648039-3707514 ~-59K 13426(TRAP1)(-)Loci: 4206 3717719-3870723 ~-153K 13429(CREBBP)(-)Loci: 4202 2962794-2970475 ~-8K 13372(PKMYT1)(-)Link out to UCSC