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0TRA2B_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSFRS10
DescriptionArginine/serine-rich splicing factor 10 (transformer-2-beta) (htra2- beta) (transformer 2 protein homolog).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (IDA)
0000398 nuclear mRNA splicing, via spliceosome (IDA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Many eukaryotic proteins that are known or supposed to bind single-stranded RNA contain one or more copies of a putative RNA-binding domain of about 90 amino acids. This is known as the eukaryotic putative RNA-binding region RNP-1 signature or RNA recognition motif (RRM). RRMs are found in a variety of RNA binding proteins.ncluding heterogeneous nuclear ribonucleoproteins (hnRNPs).roteins implicated in regulation of alternative splicing.nd protein components of small nuclear ribonucleoproteins (snRNPs). The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialized features for protein recognition . The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich.ith a third helix present during RNA binding in some cases .
  IPR000504:RNA-binding region RNP-1 (RNA recognition motif)
This entry represents nucleotide-binding domains with an alpha-beta plait structure.hich consists of either a ferredoxin-like (beta-alpha-beta)2 fold.uch as that found in RNA-binding domains of various ribonucleoproteins or in viral DNA-binding domains . or a beta-(alpha)-beta-alpha-beta(2) fold.uch as that found in the ribosomal protein L23 .
  IPR012677:Nucleotide-binding, alpha-beta plait
IPR000504:RRM_1 
Evalue:-28.2291488647461 
Location:120-191
SequencesProtein: TRA2B_HUMAN (288 aa)
mRNA: NM_004593
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 325 residues, 187117235-187118207Exon2: 26 residues, 187118846-187118920Exon3: 22 residues, 187119918-187119978Exon4: 30 residues, 187121585-187121669Exon5: 40 residues, 187122492-187122608Exon6: 65 residues, 187124277-187124466Exon7: 56 residues, 187125945-187126108Exon8: 46 residues, 187127082-187127216Exon9: 50 residues, 187138306-187138450Exon10: 2 residues, -Jump to TRA2B_HUMAN  
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Loci Cluster (Details)Loci: 4653 187349939-187521190 ~-171K 26985(-)Loci: 3393 187813580-187821799 ~-8K 26990(AHSG)(+)Loci: 4652 187117235-187138450 ~-21K 26980(SFRS10)(-)Link out to UCSC