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0TPPC4_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionTrafficking protein particle complex subunit 4 (synbindin) (trs23 homolog) (hematopoietic stem/progenitor cell protein 172).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0030425 dendrite (ISS)
0005795 Golgi stack (ISS)
0045202 synapse (ISS)
0008021 synaptic vesicle (ISS)
0005515 protein binding (ISS)
0016358 dendrite morphogenesis (ISS)
0045212 neurotransmitter receptor biosynthesis (ISS)
0016192 vesicle-mediated transport (ISS)

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Domain Architecture (Details)
InterPro domains assigned to SynO:
Sybindin is a physiological syndecan-2 ligand on dendritic spines.he small protrusions on the surface of dendrites that receive the vast majority of excitatory synapses. Syndecan-2 induces spine formation by recruiting intracellular vesicles toward postsynaptic sites through the interaction with synbindin .
  IPR007233:Sybindin-like protein
VAMPs (and its homologue synaptobrevins) define a group of SNARE proteins that contain a C-terminal coiled-coil/SNARE motif.n combination with variable N-terminal domains that are used to classify VAMPs: those containing longin N-terminal domains (~150 aa) are referred to as longins.hile those with shorter N-termini are referred to as brevins . Longins are the only type of VAMP protein found in all eukaryotes.uggesting that their longin domain is essential. The longin domain is thought to exert a regulatory function. Longin domains have been shown to share the same structural fold. profilin-like globular domain consisting of a five-stranded antiparallel beta-sheet that is sandwiched by an alpha-helix on one side.nd two alpha-helices on the other (beta(2)-alpha-beta(3)-alpha(2)).Other families have been shown to contain domains that structurally resemble the VAMP longin domain. An example is the eukaryotic conserved protein.EDL.hich is a component of the transport protein particle (TRAPP).ritically involved in endoplasmic reticulum-to-Golgi vesicle transport; mutations in the SEDL gene are associated with an X-linked skeletal disorder.pondyloepiphyseal dysplasia tarda . Another example is the assembly domain of clathrin coat proteins.uch as Mu2 adaptin (AP50) and Sigma2 adaptin (AP17).hich structurally resemble the longin domain. AP50 and AP17 are two of the proteins that make up the core of AP2. complex that functions in clathrin-mediated endocytosis .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
SequencesProtein: TPPC4_HUMAN (219 aa)
mRNA: NM_016146
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords,domains)
Any process that activates or increases the rate, frequency or extent of synaptic growth at neuromuscular junction.
sdb:0047 positive regulation of synaptic growth at neuromuscular junction  (Evidence:keywords,domains)
Fusion of intracellular membrane-bound vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
sdb:0049 synaptic vesicle fusion  (Evidence:keywords,domains)
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords,domains)
interaction between synaptic vesicle and the scaffold.
sdb:0106 transport of synaptic vesicle in the presynaptic axon  (Evidence:keywords,domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:keywords,domains)
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:keywords,domains)
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 147 residues, 118394450-118394890Exon2: 60 residues, 118395062-118395237Exon3: 36 residues, 118396069-118396173Exon4: 44 residues, 118397679-118397806Exon5: 119 residues, 118399240-118399592Exon6: 2 residues, -Jump to TPPC4_HUMAN  
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Loci Cluster (Details)Loci: 3997 117509303-117528745 ~-19K 7842(SCN4B)(-)Loci: 3998 117538729-117552546 ~-14K 7844(SCN2B)(-)Loci: 2710 117720310-117729261 ~-9K 7856(CD3G)(+)Loci: 2711 117812414-117901144 ~-89K 7860(MLL)(+)Loci: 2712 117948320-117978854 ~-31K 7867(ARCN1)(+)Loci: 2713 118394450-118399592 ~-5K 7892(TRAPPC4)(+)Loci: 3999 118794097-118799064 ~-5K 7924(THY1)(-)Loci: 2709 117452975-117494380 ~-41K 7838(TMPRSS4)(+)Link out to UCSC