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0TPP1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCLN2
DescriptionTripeptidyl-peptidase i precursor (ec 3.4.14.9) (tpp-i) (tripeptidyl aminopeptidase) (lysosomal pepstatin insensitive protease) (lpic) (growth-inhibiting protein 1) (gig1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005764 lysosome (TAS)
0008233 peptidase activity (TAS)
0006629 lipid metabolism (TAS)
0007399 neurogenesis (TAS)
0006508 proteolysis and peptidolysis (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Peptide proteinase inhibitors can be found as single domain proteins or as single or multiple domains within proteins; these are referred to as either simple or compound inhibitors.espectively. In many cases they are synthesised as part of a larger precursor protein.ither as a prepropeptide or as an N-terminal domain associated with an inactive peptidase or zymogen. Removal of the N-terminal inhibitor domain either by interaction with a second peptidase or by autocatalytic cleavage activates the zymogen. Proteinase propeptide inhibitors (sometimes refered to as activation peptides) are responsible for the modulation of folding and activity of the pro-enzyme or zymogen. The pro-segment docks into the enzyme moiety shielding the substrate binding site.hereby promoting inhibition of the enzyme. Several such propeptides share a similar topology .espite often low sequence identities . The propeptide region has an open-sandwich antiparallel-alpha/antiparallel-beta fold.ith two alpha-helices and four beta-strands with a (beta/alpha/beta)x2 topology.This propeptide inhibitor domain occurs widely across all forms of life.nd is found associated with the N-terminal region of a number of MEROPS peptidase families: Metallopeptidase family M14A (carboxypeptidases). These include carboxypeptidase A1.2 .3.4.5.6..nsect gut carboxypeptidase and B . Serine peptidase family S8A (subtilisin family). Members of this group belong to MEROPS inhibitor family I9.lan I-.Serine peptidase family S8B (kexin family). The calcium-dependant serine peptidases belonging to MEROPS family S8B include the Kex2/subtilisin-like proprotein convertase (PC) family.hich have been identified in all eukaryotes.hese include furin.C1/3.nd PC2. The convertases are synthesised as an “inactive precursor proteins or zymogens. Following the N-terminal signal peptide is the prodomain.onsisting of between 80 to 115 residues; it is an integral part ofthe zymogen and acts as a steric chaperone to aid proper folding of the zymogen. An autocatalytic cleavage at the second dibasic site.-X-K-R.iberates the prodomain.ut which remains attached and acts to inhibit any further endopeptidase activity by binding to the catalytic domain. Inhibition is released when the maturing convertase is transported to the trans-Golgi network (TGN) where a decrease in pH causes a second autoproteolytic cleavage to occur at the first dibasic site within the prodomain fragment . The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR009020:Proteinase inhibitor, propeptide
IPR009020:Prot_inh_propept 
Evalue:0 
Location:19-196
SequencesProtein: TPP1_HUMAN (563 aa)
mRNA: NM_000391
Local Annotation
Synapse Ontology
Microglias, one kind of glias in CNS, are responsible for removing most of the waste and cellular debris from the CNS
sdb:0267 removing metabolic mass  (Evidence:keywords)
KO assignmentK01279
  Level 3 annotation:
    tripeptidyl-peptidase I
  Level 2 annotation:
    Other amino acid metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 640 residues, 6590575-6592493Exon2: 44 residues, 6592672-6592798Exon3: 55 residues, 6592977-6593136Exon4: 42 residues, 6593248-6593369Exon5: 25 residues, 6593811-6593881Exon6: 65 residues, 6594121-6594310Exon7: 68 residues, 6594467-6594666Exon8: 61 residues, 6594781-6594960Exon9: 44 residues, 6595107-6595235Exon10: 52 residues, 6595432-6595583Exon11: 48 residues, 6596582-6596722Exon12: 26 residues, 6597002-6597074Exon13: 17 residues, 6597190-6597236Exon14: 2 residues, -Jump to TPP1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3934 6599133-6633650 ~-35K 6270(DCHS1)(-)Loci: 3935 6772331-6773715 ~-1K 6274(OR6A2)(-)Loci: 3933 6590575-6597236 ~-7K 6266(CLN2)(-)Link out to UCSC