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0TPIS_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionTriosephosphate isomerase (ec (tim) (triose-phosphate isomerase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004807 triose-phosphate isomerase activity (NAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Triosephosphate isomerase () (TIM) is the glycolytic enzyme that catalyzes thereversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production. It is a dimer of identical subunits.ach of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism . The sequence around the active site residue is perfectly conserved in all known TIMs. Deficiencies in TIM are associated with haemolytic anaemia coupled with a progressive.evere neurological disorder .
  IPR000652:Triosephosphate isomerase
SequencesProtein: TPIS_HUMAN (248 aa)
mRNA: NM_000365
Local Annotation
Synapse Ontology
the generation of action potential at soma of neurons.
sdb:0313 generation of AP at soma  (Evidence:keywords)
KO assignmentK01803
  Level 3 annotation:
    triosephosphate isomerase (TIM)
  Level 2 annotation:
    Glycolysis / Gluconeogenesis
    Fructose and mannose metabolism
    Inositol metabolism
    Carbon fixation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 47 residues, 6846966-6847106Exon2: 43 residues, 6848288-6848412Exon3: 30 residues, 6848523-6848608Exon4: 46 residues, 6848682-6848815Exon5: 30 residues, 6849112-6849198Exon6: 31 residues, 6849473-6849561Exon7: 190 residues, 6849689-6850253Exon8: 2 residues, -Jump to TPIS_HUMAN  
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Loci Cluster (Details)Loci: 4009 6326275-6354976 ~-29K 8222(SCNN1A)(-)Loci: 2731 6424326-6431144 ~-7K 8225(TNFRSF7)(+)Loci: 4010 6441666-6450104 ~-8K 8228(VAMP1)(-)Loci: 4011 6518966-6535498 ~-17K 8239(-)Loci: 4012 6549509-6586812 ~-37K 8245(CHD4)(-)Loci: 4013 6598261-6615548 ~-17K 8247(GPR92)(-)Loci: 2732 6703481-6711289 ~-8K 8256(COPS7A)(+)Loci: 2733 6846966-6850253 ~-3K 8271(TPI1)(+)Loci: 2734 7174236-7201985 ~-28K 8292(CLSTN3)(+)Loci: 4008 5928407-6103946 ~-176K 8213(VWF)(-)Link out to UCSC