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0TNR9_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTNFRSF9
DescriptionTumor necrosis factor receptor superfamily member 9 precursor (4-1bb ligand receptor) (t-cell antigen 4-1bb homolog) (t-cell antigen ila) (cd137 antigen).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0004872 receptor activity (TAS)
0006917 induction of apoptosis (TAS)
0008285 negative regulation of cell proliferation (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
A number of proteins.ome of which are known to be receptors for growth factors have been found to contain a cysteine-rich domain at the N-terminal region that can be subdivided into four (or in some cases.hree) repeats containing six conservedcysteines all of which are involved in intrachain disulphide bonds . CD27 (also called S152 or T14) mediates a co-stimulatory signal for T and B cell activation and is involved in murine T cell development. Tyrosine-phosphorylation of ZAP-70 following CD27 ligation of T cells has been reported .ut not confirmed independently. CD30 was originally identified as Ki-1.n antigen expressed on Reed-Sternberg cells in Hodgkins lymphomas and other non-Hodgkins lymphomas.articularly diffuse large-cell lymphoma and immunoblastic lymphoma. CD30 has pleiotropic effects on CD30-positive lymphoma cell lines ranging from cell proliferation to cell death. It is thought to be involved in negative selection of T-cells in the thymus and is involved in TCR-mediated cell death. CD30 is a member of the TNFR family of molecules.ctivate NFkB through interaction with TRAF2 and TRAF5. CD40 (Bp50) plays a central role in the regulation of cell-mediated immunity as well as antibody mediated immunity. It is central to T cell dependent (TD)-responses and may influence survival of B cell lymphomas. CD95 (also called APO-1.as antigen.as tumor necrosis factor receptor superfamily.ember 6.NFRSF6 or apoptosis antigen 1.PT1) is expressed.ypically at high levels.n activated T and B cells. It is involved in the mediation of apoptosis-inducing signals. Other proteins known to belong to this family .re.umor Necrosis Factor type I and type II receptors (TNFR).hope fibroma virus soluble TNF receptor (protein T2).ymphotoxin alpha/beta receptor.ow-affinity nerve growth factor receptor (LA-NGFR) (p75).-cell antigen OX40.sl-1. receptor (for a yet undefined ligand) that mediates apoptosis and Vaccinia virus protein A53 (SalF19R).CD molecules are leucocyte antigens on cell surfaces. CD antigens nomenclature is updated at http://www.ncbi.nlm.nih.gov/PROW/guide/45277084.htm
  IPR001368:TNFR/CD27/30/40/95 cysteine-rich region
IPR001368:TNFR 
Evalue:-5.38721614328026 
Location:120-158IPR001368:TNFR 
Evalue:-5.17392519729917 
Location:48-86IPR006058:2FE2S_FER_1 
Evalue:0 
Location:94-102
SequencesProtein: TNR9_HUMAN (255 aa)
mRNA: NM_001561
Local Annotation
Synapse Ontology
A typical resting membrane potential for neurons varies from -65 to -90 mV. This potential represents the sum of the equilibrium potentials for each contributing ion.
sdb:0237 resting membrane potentiaion  (Evidence:keywords)
KO assignmentK05146
  Level 3 annotation:
    tumor necrosis factor receptor superfamily, member 9
  Level 2 annotation:
    Cytokine receptors
    Cytokine-cytokine receptor interaction
    CD molecules
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 359 residues, 7902494-7903570Exon2: 47 residues, 7915808-7915943Exon3: 45 residues, 7917659-7917790Exon4: 24 residues, 7920336-7920403Exon5: 48 residues, 7920839-7920977Exon6: 38 residues, 7921367-7921475Exon7: 63 residues, 7922541-7922725Exon8: 16 residues, 7923430-7923474Exon9: 2 residues, -Jump to TNR9_HUMAN  
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Loci Cluster (Details)Loci: 3768 7830261-7835682 ~-5K 298(UTS2)(-)Loci: 3769 7902494-7923474 ~-21K 300(TNFRSF9)(-)Loci: 2478 7944379-7967923 ~-24K 301(PARK7)(+)Loci: 2477 7753915-7764078 ~-10K 293(VAMP3)(+)Link out to UCSC