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0TNR7_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTNFRSF7
DescriptionTumor necrosis factor receptor superfamily member 7 precursor (cd27l receptor) (t-cell activation antigen cd27) (t14).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005576 extracellular region (NAS)
0005887 integral to plasma membrane (NAS)
0043027 caspase inhibitor activity (IDA)
0005515 protein binding (IPI)
0004888 transmembrane receptor activity (NAS)
0042100 B cell proliferation (ISS)
0007166 cell surface receptor linked signal transdu... (NAS)
0016064 humoral defense mechanism (sensu Vertebrata) (NAS)
0048305 immunoglobulin secretion (ISS)
0006917 induction of apoptosis (ISS)
0001719 inhibition of caspase activation (IDA)
0045579 positive regulation of B cell differentiation (NAS)
0045078 positive regulation of interferon-gamma bio... (ISS)
0046330 positive regulation of JNK cascade (ISS)
0045582 positive regulation of T cell differentiation (ISS)
0008588 release of cytoplasmic sequestered NF-kappaB (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
A number of proteins.ome of which are known to be receptors for growth factors have been found to contain a cysteine-rich domain at the N-terminal region that can be subdivided into four (or in some cases.hree) repeats containing six conservedcysteines all of which are involved in intrachain disulphide bonds . CD27 (also called S152 or T14) mediates a co-stimulatory signal for T and B cell activation and is involved in murine T cell development. Tyrosine-phosphorylation of ZAP-70 following CD27 ligation of T cells has been reported .ut not confirmed independently. CD30 was originally identified as Ki-1.n antigen expressed on Reed-Sternberg cells in Hodgkins lymphomas and other non-Hodgkins lymphomas.articularly diffuse large-cell lymphoma and immunoblastic lymphoma. CD30 has pleiotropic effects on CD30-positive lymphoma cell lines ranging from cell proliferation to cell death. It is thought to be involved in negative selection of T-cells in the thymus and is involved in TCR-mediated cell death. CD30 is a member of the TNFR family of molecules.ctivate NFkB through interaction with TRAF2 and TRAF5. CD40 (Bp50) plays a central role in the regulation of cell-mediated immunity as well as antibody mediated immunity. It is central to T cell dependent (TD)-responses and may influence survival of B cell lymphomas. CD95 (also called APO-1.as antigen.as tumor necrosis factor receptor superfamily.ember 6.NFRSF6 or apoptosis antigen 1.PT1) is expressed.ypically at high levels.n activated T and B cells. It is involved in the mediation of apoptosis-inducing signals. Other proteins known to belong to this family .re.umor Necrosis Factor type I and type II receptors (TNFR).hope fibroma virus soluble TNF receptor (protein T2).ymphotoxin alpha/beta receptor.ow-affinity nerve growth factor receptor (LA-NGFR) (p75).-cell antigen OX40.sl-1. receptor (for a yet undefined ligand) that mediates apoptosis and Vaccinia virus protein A53 (SalF19R).CD molecules are leucocyte antigens on cell surfaces. CD antigens nomenclature is updated at http://www.ncbi.nlm.nih.gov/PROW/guide/45277084.htm
  IPR001368:TNFR/CD27/30/40/95 cysteine-rich region
In mammals.he second stage of spermatogenesis is characterized by the conversion of nucleosomalchromatin to the compact.onnucleosomal and transcriptionally inactive form found in the sperm nucleus.This condensation is associated with a double-protein transition. The first transition corresponds to thereplacement of histones by several spermatid-specific proteins.lso called transition proteins.hich arethemselves replaced by protamines during the second transition. Nuclear transition protein 2 (TP2) is oneof those spermatid-specific proteins. TP2 is a basic.inc-binding protein of 116 to 137amino-acid residues. Structurally.P2 consists of three distinct parts. conserved serine-rich N-terminaldomain of about 25 residues. variable central domain of 20 to 50 residues which contains cysteine residues.nd a conserved C-terminal domain of about 70 residues rich in lysines and arginines.
  IPR000678:Nuclear transition protein 2
Like all apoptotic cell death. cell receptor (TCR)-mediated death can bedivided into two phases: an inductive phase and an effector phase. The effector phase includes a sequence of steps that are common to apoptosis inmany cell types.hich.f not interrupted.ill lead to cell death. Theinduction phase.hich often requires the expression of new genes.onsistsof a set of signals that activate the effector phase. Outside the thymus.ost.f not all.f the TCR-mediated apoptosis of mature T cells (sometimesreferred to as activation-induced cell death (AICD)) is induced through thesurface antigen Fas pathway: activation through the TCR induces expressionof the Fas (CD95) ligand (FasL); the expression of FasL on either aneighbouring cell.r on the Fas-bearing cell.nduces trimerisation of Fas.hich then initiates a signal-transduction cascade.eading to apoptosis of the Fas-bearing cell. This commitment stage requires the activation of keydeath-inducing enzymes.ermed caspases.hich act by cleaving proteins that are essential for cell survival and proliferation.Fas is also known to be essential in the death of hyperactivated peripheralCD4+ cells: in the absence of Fas.ature peripheral T cells do not die.utthe activated cells continue to proliferate.roducing cytokines that leadto grossly enlarged lymph nodes and spleen. Fas belongs to the tumournecrosis factor receptor (TNFR) family of cysteine-rich type I membranereceptors; its ligand (FasL) is expressed on activated lymphocytes.K cells.latelets.ertain immune-privileged cells and some tumour cells .Defects in the Fas-FasL system are associated with various disease syndromes.Mice with non-functional Fas or FasL display characteristics of lympho-proliferative disorder.uch as lymphadenopathy.plenomegaly.nd elevated secretion of IgM and IgG. These mice also secrete anti-DNA autoantibodiesand rheumatoid factor .
  IPR008063:Fas receptor
IPR001368:TNFR_c6 
Evalue:-10.958607673645 
Location:65-104IPR001368:TNFR_c6 
Evalue:-9.60206031799316 
Location:27-62
SequencesProtein: TNR7_HUMAN (260 aa)
mRNA: NM_001242
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
Typical ecretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of nonpeptide neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
sdb:0094 typical synaptic vesicle  (Evidence:keywords)
KO assignmentK05144
  Level 3 annotation:
    tumor necrosis factor receptor superfamily, member 7
  Level 2 annotation:
    Cytokine receptors
    Cytokine-cytokine receptor interaction
    CD molecules
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 111 residues, 6424326-6424658Exon2: 46 residues, 6424850-6424982Exon3: 62 residues, 6429599-6429779Exon4: 32 residues, 6429967-6430057Exon5: 42 residues, 6430321-6430441Exon6: 152 residues, 6430694-6431144Exon7: 2 residues, -Jump to TNR7_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4009 6326275-6354976 ~-29K 8222(SCNN1A)(-)Loci: 2731 6424326-6431144 ~-7K 8225(TNFRSF7)(+)Loci: 4010 6441666-6450104 ~-8K 8228(VAMP1)(-)Loci: 4011 6518966-6535498 ~-17K 8239(-)Loci: 4012 6549509-6586812 ~-37K 8245(CHD4)(-)Loci: 4013 6598261-6615548 ~-17K 8247(GPR92)(-)Loci: 2732 6703481-6711289 ~-8K 8256(COPS7A)(+)Loci: 2733 6846966-6850253 ~-3K 8271(TPI1)(+)Loci: 2734 7174236-7201985 ~-28K 8292(CLSTN3)(+)Loci: 4008 5928407-6103946 ~-176K 8213(VWF)(-)Link out to UCSC