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0TNR16_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNGFR
DescriptionTumor necrosis factor receptor superfamily member 16 precursor (low- affinity nerve growth factor receptor) (ngf receptor) (gp80-lngfr) (p75 icd) (low affinity neurotrophin receptor p75ntr).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005886 plasma membrane (TAS)
0004888 transmembrane receptor activity (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The death domain (DD) is a conserved region of about 80 residues found on death receptors.nd which is required for death signalling.s well as a variety of non-apoptotic functions . Proteins containing this domain include the low affinity neurotrophin receptor p73.as.ADD (Fas-associated death domain protein).NF-1 (tumour necrosis factor receptor-1).elle protein kinase.nd the Tube adaptor protein .The induction of apoptosis also relies on the presence of a second domain.alled the death effector domain. The death effector domain (DED) occurs in proteins that regulate programmed cell death.ncluding both pro- and anti-apoptotic proteins; many of these proteins are also involved in controlling cellular activation and proliferation pathways . Proteins containing this domain include FADD (DED N-terminal.D C-terminal).EA-15 (phosphoproteins enriched in astrocytes 15kDa).aspases and FLIP.The induction of apoptosis results in the activation of caspases. family of aspartyl-specific cysteine proteases that are the main executioners of apoptosis. For example.he DED of FADD recruits two DED-containing caspases.aspase-8 and caspase-10.o form the death-inducing signal complex.hich initiates apoptosis. Proteins containing the caspase recruitment domain (CARD) are involved in the recruitment and activation of caspases during apoptosis . Other CARD proteins participate in NF-kappaB signalling pathways associated with innate or adaptive immune responses. Proteins containing CARD include Raidd.PAF-1 (apoptotic protease activating factor 1).rocaspase 9 and iceberg (inhibitor of interleukin-1-beta generation).The DD shows strong structural similarity to both DED and CARD. They all display a 6-helical closed bundle fold.ith greek key topology and an internal psuedo two-fold symmetry. However.espite their overall similarity in topology.ach domain forms specialised interactions.ypically only with members of its own subfamily.or example DED with DED.Please be aware that some of the proteins hit by the SSF signature may be false positives.
  IPR011029:DEATH-like
The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD is related in sequence and structure to the death effector domain (DED.ee ) and the caspase recruitment domain (CARD.ee ).hich work in similar pathways and show similar interaction properties . DD bind each other forming oligomers. Mammals have numerous and diverse DD-containing proteins . Within these proteins.he DD domains can be found in combination with other domains.ncluding: CARDs.EDs.nkyrin repeats ().aspase-like folds.inase domains.eucine zippers ().eucine-rich repeats (LRR) ().IR domains ().nd ZU5 domains () .Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB.hich typically involves interactions with TNF (tumour necrosis factor) cytokine receptors . In humans.ight of the over 30 known TNF receptors contain DD in their cytoplasmic tails; several of these TNF receptors use caspase activation as a signalling mechanism. The DD mediates self-association of these receptors.hus giving the signal to downstream events that lead to apoptosis. Other DD-containing proteins.uch as ankyrin.yD88 and pelle.re probably not directly involved in cell death signalling. DD-containing proteins also have links to innate immunity.ommunicating with Toll family receptors through bipartite adapter proteins such as MyD88 .
  IPR000488:Death
A number of proteins.ome of which are known to be receptors for growth factors have been found to contain a cysteine-rich domain at the N-terminal region that can be subdivided into four (or in some cases.hree) repeats containing six conservedcysteines all of which are involved in intrachain disulphide bonds . CD27 (also called S152 or T14) mediates a co-stimulatory signal for T and B cell activation and is involved in murine T cell development. Tyrosine-phosphorylation of ZAP-70 following CD27 ligation of T cells has been reported .ut not confirmed independently. CD30 was originally identified as Ki-1.n antigen expressed on Reed-Sternberg cells in Hodgkins lymphomas and other non-Hodgkins lymphomas.articularly diffuse large-cell lymphoma and immunoblastic lymphoma. CD30 has pleiotropic effects on CD30-positive lymphoma cell lines ranging from cell proliferation to cell death. It is thought to be involved in negative selection of T-cells in the thymus and is involved in TCR-mediated cell death. CD30 is a member of the TNFR family of molecules.ctivate NFkB through interaction with TRAF2 and TRAF5. CD40 (Bp50) plays a central role in the regulation of cell-mediated immunity as well as antibody mediated immunity. It is central to T cell dependent (TD)-responses and may influence survival of B cell lymphomas. CD95 (also called APO-1.as antigen.as tumor necrosis factor receptor superfamily.ember 6.NFRSF6 or apoptosis antigen 1.PT1) is expressed.ypically at high levels.n activated T and B cells. It is involved in the mediation of apoptosis-inducing signals. Other proteins known to belong to this family .re.umor Necrosis Factor type I and type II receptors (TNFR).hope fibroma virus soluble TNF receptor (protein T2).ymphotoxin alpha/beta receptor.ow-affinity nerve growth factor receptor (LA-NGFR) (p75).-cell antigen OX40.sl-1. receptor (for a yet undefined ligand) that mediates apoptosis and Vaccinia virus protein A53 (SalF19R).CD molecules are leucocyte antigens on cell surfaces. CD antigens nomenclature is updated at http://www.ncbi.nlm.nih.gov/PROW/guide/45277084.htm
  IPR001368:TNFR/CD27/30/40/95 cysteine-rich region
IPR011029:DEATH_like 
Evalue:-28.8239078521729 
Location:333-420IPR001368:TNFR_c6 
Evalue:-12.5376024246216 
Location:149-188IPR001368:TNFR_c6 
Evalue:-11.2839965820313 
Location:109-146IPR001368:TNFR_c6 
Evalue:-8.06550121307373 
Location:67-107IPR001368:TNFR_c6 
Evalue:-6.45593214035034 
Location:32-64IPR008262:LIPASE_SER 
Evalue:0 
Location:18-27
SequencesProtein: TNR16_HUMAN (427 aa)
mRNA: NM_002507
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentK02583
  Level 3 annotation:
    nerve growth factor receptor (TNFR superfamily, member 16)
  Level 2 annotation:
    Cytokine receptors
    Cytokine-cytokine receptor interaction
    CD molecules
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 60 residues, 44927665-44927844Exon2: 49 residues, 44934423-44934565Exon3: 122 residues, 44938659-44939019Exon4: 86 residues, 44942772-44943025Exon5: 55 residues, 44944252-44944413Exon6: 766 residues, 44945068-44947360Exon7: 2 residues, -Jump to TNR16_HUMAN  
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