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0TLN2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTLN2
DescriptionTalin-2.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0015629 actin cytoskeleton (NAS)
0045202 synapse (NAS)
0003779 actin binding (NAS)
0005515 protein binding (IPI)
0005198 structural molecule activity (NAS)
0007155 cell adhesion (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found in a number of cytoskeletal-associated proteins that associate with various proteins at the interface between the plasma membrane and the cytoskeleton. It is a conserved N-terminal domain of about 150 residues .nvolved in the linkage of cytoplasmic proteins to the membrane.
  IPR000299:Band 4.1
I/LWEQ domains bind to actin. It has been shown that the I/LWEQdomains from mouse talin and yeast Sla2p interact with F-actin . The domain has four conserved blocks.he name of the domain is derived from the initial conserved amino acid ofeach of the four blocks . I/LWEQ domains can beplaced into four major groups based on sequence similarity:Metazoan talin.Dictyostelium discoideum TalA/TalB and SLA110.Metazoan Hip1p .Saccharomyces cerevisiae Sla2p .
  IPR002558:I/LWEQ
FERM domains (band F ezrin-radixin-moesin homology domains) are a common membrane-binding module involved in localising proteins to the plasma membrane . Proteins containing a FERM domain include cytoskeletal proteins such as erythrocyte membrane protein 4.1R.alin.nd the ezrin-radixin-moesin protein family.s well as several protein tyrosine kinases and phosphatases.nd the neurofibromatosis 2 tumour suppressor protein merlin. The ezrin-radixin-moesin protein family function to crosslink the actin filaments of cytoskeletal structures to the plasma membrane.
  IPR009065:FERM
IPR002558:I_LWEQ 
Evalue:-100.420219421387 
Location:2342-2533IPR000299:Band_41 
Evalue:-85.6020584106445 
Location:123-316IPR002558:ILWEQ 
Evalue:0 
Location:1424-1624IPR006650:A_DEAMINASE 
Evalue:0 
Location:2069-2075IPR000299:FERM_1 
Evalue:0 
Location:0-0
SequencesProtein: TLN2_HUMAN (2542 aa)
mRNA: NM_015059
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
KO assignmentK06271
  Level 3 annotation:
    talin
  Level 2 annotation:
    Focal adhesion
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 46 residues, 60726801-60726937Exon2: 34 residues, 60729574-60729672Exon3: 45 residues, 60731495-60731625Exon4: 53 residues, 60732652-60732805Exon5: 49 residues, 60735434-60735577Exon6: 44 residues, 60737261-60737389Exon7: 23 residues, 60753317-60753381Exon8: 37 residues, 60754707-60754812Exon9: 54 residues, 60766131-60766287Exon10: 36 residues, 60772330-60772432Exon11: 27 residues, 60773806-60773883Exon12: 62 residues, 60777178-60777359Exon13: 40 residues, 60778244-60778358Exon14: 38 residues, 60780596-60780705Exon15: 71 residues, 60781482-60781691Exon16: 35 residues, 60782256-60782355Exon17: 58 residues, 60786576-60786744Exon18: 100 residues, 60787992-60788287Exon19: 57 residues, 60791401-60791568Exon20: 45 residues, 60795821-60795950Exon21: 40 residues, 60797066-60797180Exon22: 40 residues, 60799257-60799371Exon23: 47 residues, 60801843-60801978Exon24: 45 residues, 60804466-60804595Exon25: 36 residues, 60806577-60806680Exon26: 71 residues, 60816368-60816577Exon27: 42 residues, 60817704-60817824Exon28: 68 residues, 60818838-60819036Exon29: 48 residues, 60820120-60820260Exon30: 33 residues, 60827841-60827935Exon31: 32 residues, 60829892-60829982Exon32: 43 residues, 60831795-60831918Exon33: 50 residues, 60833263-60833407Exon34: 56 residues, 60835022-60835184Exon35: 49 residues, 60841171-60841312Exon36: 62 residues, 60841762-60841944Exon37: 46 residues, 60843053-60843186Exon38: 36 residues, 60845811-60845913Exon39: 59 residues, 60850454-60850625Exon40: 51 residues, 60856015-60856162Exon41: 36 residues, 60860391-60860493Exon42: 42 residues, 60863022-60863142Exon43: 51 residues, 60871892-60872039Exon44: 57 residues, 60875378-60875545Exon45: 63 residues, 60876470-60876654Exon46: 44 residues, 60879619-60879745Exon47: 41 residues, 60879904-60880021Exon48: 64 residues, 60884851-60885037Exon49: 38 residues, 60889176-60889284Exon50: 37 residues, 60898767-60898873Exon51: 43 residues, 60899737-60899862Exon52: 44 residues, 60912755-60912881Exon53: 23 residues, 60914988-60915051Exon54: 63 residues, 60915142-60915325Exon55: 44 residues, 60918107-60918233Exon56: 335 residues, 60919733-60920733Exon57: 2 residues, -Jump to TLN2_HUMAN  
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