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0TIM44_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTIMM44
DescriptionImport inner membrane translocase subunit tim44, mitochondrial precursor.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005759 mitochondrial matrix (TAS)
0006626 protein-mitochondrial targeting (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane . Tim44 is thought to bind phospholipids of the mitochondrial inner membrane both by electrostatic interactions and by penetrating the polar head group region .
  IPR007379:Mitochondrial import inner membrane translocase, subunit Tim44
The mitochondrial protein translocase (MPT) family.hich brings nuclearly encoded preproteins into mitochondria.s very complex with 19 currently identified protein constituents. These proteins include several chaperone proteins.our proteins of the outer membrane translocase (Tom) import receptor.ive proteins of the Tom channel complex.ive proteins of the inner membrane translocase (Tim) and three "motor" proteins.The inner membrane translocase is formed of a complex with a number of proteins.ncluding the Tim17.im23 and Tim44 subunits. Tim17 and Tim23 are thought to form the translocation channel of the inner membrane.
  IPR005682:Mitochondrial import inner membrane translocase, subunit Tim44, subtype
IPR007379:Tim44 
Evalue:-64.3187561035156 
Location:296-445
SequencesProtein: TIM44_HUMAN (452 aa)
mRNA: NM_006351
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 197 residues, 7897603-7898191Exon2: 39 residues, 7898541-7898652Exon3: 32 residues, 7898961-7899051Exon4: 19 residues, 7902022-7902073Exon5: 43 residues, 7903511-7903636Exon6: 33 residues, 7903724-7903817Exon7: 30 residues, 7904369-7904455Exon8: 48 residues, 7904748-7904888Exon9: 52 residues, 7904973-7905123Exon10: 29 residues, 7905949-7906030Exon11: 59 residues, 7908911-7909082Exon12: 34 residues, 7911986-7912082Exon13: 17 residues, 7914491-7914538Exon14: 2 residues, -Jump to TIM44_HUMAN  
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Loci Cluster (Details)Loci: 3084 7493511-7504871 ~-11K 17845(MCOLN1)(+)Loci: 3085 7608012-7618758 ~-11K 17854(STXBP2)(+)Loci: 4362 7897603-7914538 ~-17K 17882(TIMM44)(-)Loci: 3086 8361295-8374479 ~-13K 17895(RAB11B)(+)Loci: 4361 7067641-7245011 ~-177K 17833(INSR)(-)Link out to UCSC