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0TIM23_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTIMM23
DescriptionMitochondrial import inner membrane translocase subunit tim23.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (TAS)
0005744 mitochondrial inner membrane presequence tr... (TAS)
0006626 protein-mitochondrial targeting (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The membrane-embedded multi-protein complexes of mitochondria mediate the transport of nuclear-encoded proteins across and into the outer or inner mitochondrial membranes . The TOM (translocase of the outer mitochondrial membrane) complex consists of cytosol-exposed receptors and a pore-forming core.nd mediates the transport of proteins from the cytosol across and into the outer mitochondrial membrane. A novel protein complex in the outer membrane of mitochondria.alled the SAM complex (sorting and assembly machinery).s involved in the biogenesis of beta-barrel proteins of the outer membrane. Two translocases of the inner mitochondrial membrane (TIM complexes) mediate protein transport at the inner membrane. The TIM23 complex (a presequence translocase) mediates the transport of presequence-containing proteins across and into the inner membrane. TIM17 forms a part of this complex.lthough its role is not yet fully understood. The TIM22 complex (a twin-pore carrier translocase) catalyses the insertion of multi-spanning proteins that have internal targeting signals into the inner membrane. The TIM22 complex mediates the membrane insertion of multi-spanning inner-membrane proteins that have internal targeting signals.nd it uses a as an external driving force. The Tim22 subunit of the mitochondrial import inner membrane translocase is included in this family.
  IPR003397:Mitochondrial import inner membrane translocase, subunit Tim17/22
The mitochondrial protein translocase (MPT) family.hich brings nuclearly encoded preproteins into mitochondria.s very complex with 19 currently identified protein constituents. These proteins include several chaperone proteins.our proteins of the outer membrane translocase (Tom) import receptor.ive proteins of the Tom channel complex.ive proteins of the inner membrane translocase (Tim) and three "motor" proteins.The inner membrane translocase is formed of a complex with a number of proteins.ncluding the Tim17.im23 and Tim44 subunits. Tim17 and Tim23 are thought to form the translocation channel of the inner membrane.
  IPR005681:Mitochondrial import inner membrane translocase, subunit Tim23
IPR003397:Tim17 
Evalue:-44.5376014709473 
Location:66-198
SequencesProtein: TIM23_HUMAN (209 aa)
mRNA: NM_006327
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 177 residues, 51262095-51262625Exon2: 39 residues, 51276993-51277104Exon3: 21 residues, 51280398-51280457Exon4: 30 residues, 51282909-51282994Exon5: 33 residues, 51283223-51283317Exon6: 21 residues, 51290329-51290388Exon7: 78 residues, 51293114-51293342Exon8: 2 residues, -Jump to TIM23_HUMAN  
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