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0THIL_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameACAT1
DescriptionAcetyl-coa acetyltransferase, mitochondrial precursor (ec 2.3.1.9) (acetoacetyl-coa thiolase) (t2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (TAS)
0003985 acetyl-CoA C-acetyltransferase activity (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Two different types of thiolase are found both in eukaryotes and in prokaryotes: acetoacetyl-CoA thiolase () and 3-ketoacyl-CoA thiolase (). 3-ketoacyl-CoA thiolase (also called thiolase I) has a broad chain-length specificity for its substrates and is involved in degradative pathways such as fatty acid beta-oxidation. Acetoacetyl-CoA thiolase (also called thiolase II) is specific for the thiolysis of acetoacetyl-CoA and involved in biosynthetic pathways such as poly beta-hydroxybutyrate synthesis or steroid biogenesis.In eukaryotes.here are two forms of 3-ketoacyl-CoA thiolase: one located in the mitochondrion and the other in peroxisomes.There are two conserved cysteine residues important for thiolase activity. The first located in the N-terminal section of the enzymes is involved in the formation of an acyl-enzyme intermediate; the second located at the C-terminal extremity is the active site base involved in deprotonation in the condensation reaction.Mammalian nonspecific lipid-transfer protein (nsL-TP) (also known as sterol carrier protein 2) is a protein which seems to exist in two different forms: a 14 Kd protein (SCP-2) and a larger 58 Kd protein (SCP-x). The former is found in the cytoplasm or the mitochondria and is involved in lipid transport; the latter is found in peroxisomes. The C-terminal part of SCP-x is identical to SCP-2 while the N-terminal portion is evolutionary related to thiolases .
  IPR002155:Thiolase
IPR002155:Thiolase_N 
Evalue:-158.004364013672 
Location:39-299IPR002155:Thiolase_C 
Evalue:-80.5850296020508 
Location:306-426
SequencesProtein: THIL_HUMAN (427 aa)
mRNA: NM_000019
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00626
  Level 3 annotation:
    acetyl-CoA C-acetyltransferase
  Level 2 annotation:
    Pyruvate metabolism
    Propanoate metabolism
    Butanoate metabolism
    Fatty acid metabolism
    Synthesis and degradation of ketone bodies
    Valine
     leucine and isoleucine degradation
    Lysine degradation
    Tryptophan metabolism
    Benzoate degradation via CoA ligation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 50 residues, 107497467-107497615Exon2: 18 residues, 107507843-107507891Exon3: 41 residues, 107509756-107509874Exon4: 34 residues, 107510157-107510253Exon5: 35 residues, 107511078-107511179Exon6: 50 residues, 107514834-107514978Exon7: 52 residues, 107516001-107516152Exon8: 34 residues, 107517541-107517637Exon9: 40 residues, 107518373-107518487Exon10: 23 residues, 107519919-107519984Exon11: 54 residues, 107522138-107522296Exon12: 94 residues, 107523206-107523484Exon13: 2 residues, -Jump to THIL_HUMAN  
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Loci Cluster (Details)Loci: 2700 107304486-107339416 ~-35K 7690(RAB39)(+)Loci: 2701 107497467-107523484 ~-26K 7692(ACAT1)(+)Loci: 3988 107884885-107969570 ~-85K 7706(SLAC2B)(-)Loci: 3987 106878964-106941671 ~-63K 7683(-)Link out to UCSC