SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0TGFR2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTGFBR2
DescriptionTgf-beta receptor type ii precursor (ec 2.7.1.37) (tgfr-2) (tgf-beta type ii receptor).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (TAS)
0005524 ATP binding (NAS)
0005515 protein binding (IPI)
0005026 type II transforming growth factor beta rec... (TAS)
0008284 positive regulation of cell proliferation (TAS)
0006470 protein amino acid dephosphorylation (NAS)

Warning: fopen(/home/kongl/syndb/www/temp/239358439.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Activin type II receptors are proteins of around 500 residues that sharea high degree of similarity (human and mouse sequences are 99% identical).The receptor.hich is involved in transmembrane signalling.onsists ofan extracellular domain that specifically binds activin A. singlemembrane-spanning domain.nd an intracellular kinase domain withpredicted serine/threonine specificity .
  IPR000333:Activin type II receptor
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR000719:Pkinase 
Evalue:-51.2218475341797 
Location:244-538IPR000333:ACTIVIN2R 
Evalue:0 
Location:124-147
SequencesProtein: TGFR2_HUMAN (567 aa)
mRNA: NM_001024847 NM_003242
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
KO assignmentK04388
  Level 3 annotation:
    transforming growth factor, beta receptor II
  Level 2 annotation:
    MAPK signaling pathway
    TGF-beta signaling pathway
    Cytokine receptors
    Cytokine-cytokine receptor interaction
    Adherens junction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 159 residues, 30622997-30623473Exon2: 27 residues, 30639694-30639769Exon3: 58 residues, 30661242-30661411Exon4: 65 residues, 30666765-30666956Exon5: 268 residues, 30688133-30688933Exon6: 49 residues, 30690600-30690742Exon7: 44 residues, 30704879-30705007Exon8: 908 residues, 30707915-30710635Exon9: 2 residues, -Jump to TGFR2_HUMANExon1: 159 residues, 30622997-30623473Exon2: 58 residues, 30661242-30661411Exon3: 65 residues, 30666765-30666956Exon4: 268 residues, 30688133-30688933Exon5: 49 residues, 30690600-30690742Exon6: 44 residues, 30704879-30705007Exon7: 908 residues, 30707915-30710635Exon8: 2 residues, -Jump to TGFR2_HUMAN  
Tune and view alternative isoforms