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0TFAP4_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTFAP4
DescriptionTranscription factor ap-4 (activating enhancer-binding protein 4).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0003705 RNA polymerase II transcription factor acti... (TAS)
0003713 transcription coactivator activity (TAS)
0007275 development (TAS)
0006357 regulation of transcription from RNA polyme... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Basic helix-loop-helix proteins (bHLH) are a group of eukaryotic transcription factors that exert a determinative influence in a variety of developmental pathways. These transcription factors are characterised by a highly evolutionary conserved bHLH domain that mediates specific dimerisation . They facilitate the conversion of inactive monomers to trans-activating dimers at appropriate stages of development . The bHLH proteins can be classified into discrete categories. One such subdivision according to dimerisation.NA binding and expression characteristics defines seven groups . Class I proteins form dimers within the group or with class II proteins. Class II can only form heterodimers with class I factors. Class III factors are characterised by the presence of a leucine zipper () adjacent to the bHLH domain. Class IV factors may form homodimers or teterodimers with class III proteins. Class V and class VI proteins act as regulators of class I and class II factors and class VII proteins have a PAS domain ().
  IPR001092:Basic helix-loop-helix dimerisation region bHLH
The helix-loop-helix (HLH) DNA-binding domain consists of a closed bundleof four helices in a left-handed twist with two crossover connections. TheHLH domain directs dimerisation.nd is juxtaposed to basic regions tocreate a DNA interaction interface surface that recognises specific DNAsequences. Basic region/HLH (bHLH) proteins regulate diverse biologicalpathways . bHLH proteins include MyoD .REBPs (sterol regulatory element binding proteins).nd yeast Pho4 (phosphatase system) .In certain proteins the bHLH domain contains a leucine-zipper motif. ThebHLH/leucine zipper (bHLHZip) domain specifies dimerisation within a networkof proteins and determines sequence-specific DNA binding . bHLHZip domains occur in the transcription factors Myc.ad.ax and Usf . This entry is bHLHZip.hich covers the bHLH domain and the leucine zipper motif.hen present.
  IPR011598:Helix-loop-helix DNA-binding
IPR001092:HLH 
Evalue:-20.5686359405518 
Location:49-100
SequencesProtein: TFAP4_HUMAN (338 aa)
mRNA: BC010576
Local Annotation
Synapse Ontology
the generation of action potential at soma of neurons.
sdb:0313 generation of AP at soma  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 354 residues, 4247192-4248251Exon2: 54 residues, 4250091-4250247Exon3: 49 residues, 4250456-4250597Exon4: 59 residues, 4251780-4251951Exon5: 35 residues, 4252325-4252424Exon6: 57 residues, 4252537-4252703Exon7: 79 residues, 4262659-4262891Exon8: 2 residues, -Jump to TFAP4_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2921 4415882-4446774 ~-31K 13438(DNAJA3)(+)Loci: 2922 4466446-4500348 ~-34K 13441(HMOX2)(+)Loci: 4208 4872508-4927137 ~-55K 13462(PPL)(-)Loci: 4207 4247192-4262891 ~-16K 13431(TFAP4)(-)Link out to UCSC