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0TFAM_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTFAM
DescriptionTranscription factor a, mitochondrial precursor (mttfa) (mitochondrial transcription factor 1) (mttf1) (transcription factor 6-like 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (TAS)
0003700 transcription factor activity (TAS)
0006261 DNA-dependent DNA replication (TAS)
0006356 regulation of transcription from RNA polyme... (TAS)
0006390 transcription from mitochondrial promoter (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
High mobility group (HMG or HMGB) proteins are a family of relatively low molecular weight non-histone components in chromatin. HMG1 (also called HMG-T in fish) and HMG2 are two highly related proteins that bind single-stranded DNA preferentially and unwind double-stranded DNA. Although they have no sequence specificity.hey have a high affinity for bent or distorted DNA.nd bend linear DNA. HMG1 and HMG2 contain two DNA-binding HMG-box domains (A and B) that show structural and functional differences.nd have a long acidic C-terminal domain rich in aspartic and glutamic acid residues. The acidic tail modulates the affinity of the tandem HMG boxes in HMG1 and 2 for a variety of DNA targets. HMG1 and 2 appear to play important architectural roles in the assembly of nucleoprotein complexes in a variety of biological processes.or example V(D)J recombination.he initiation of transcription.nd DNA repair .The profile in this entry describing the HMG-domains is much more general than the signature. In addition to the HMG1 and HMG2 proteins.MG-domains occur in single or multiple copies in the following protein classes; the SOX family of transcription factors; SRY sex determining region Y protein and related proteins ; LEF1 lymphoid enhancer binding factor 1 ; SSRP recombination signal recognition protein; MTF1 mitochondrial transcription factor 1; UBF1/2 nucleolar transcription factors; Abf2 yeast ARS-binding factor ; and Saccharomyces cerevisiae transcription factors Ixr1.ox1.hp6a.hp6b and Spp41.
  IPR000910:HMG1/2 (high mobility group) box
High mobility group (HMG) box domains are involved in binding DNA.nd may be involved in protein-protein interactions as well. The structure of the HMG-box domain consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins.hich form a large.iverse family involved in the regulation of DNA-dependent processes such as transcription.eplication.nd strand repair.ll of which require the bending and unwinding of chromatin. Many of these proteins are regulators of gene expression. HMG-box proteins are found in a variety of eukaryotic organisms.nd can be broadly divided into two groups.ased on sequence-dependent and sequence-independent DNA recognition; the former usually contain one HMG-box motif.hile the latter can contain multiple HMG-box motifs. HMG-box domains can be found in single or multiple copies in the following protein classes: HMG1 and HMG2 non-histone components of chromatin; SRY (sex determining region Y protein) involved in differential gonadogenesis; the SOX family of transcription factors ; sequence-specific LEF1 (lymphoid enhancer binding factor 1) and TCF-1 (T-cell factor 1) involved in regulation of organogenesis and thymocyte differentiation ; structure-specific recognition protein SSRP involved in transcription and replication; MTF1 mitochondrial transcription factor; nucleolar transcription factors UBF 1/2 (upstream binding factor) involved in transcription by RNA polymerase I; Abf2 yeast ARS-binding factor ; yeast transcription factors lxr1.ox1.hp6b and Spp41; mating type proteins (MAT) involved in the sexual reproduction of fungi ; and the YABBY plant-specific transcription factors. The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR009071:High mobility group box
IPR000910:HMG_box 
Evalue:-26.1023731231689 
Location:50-118IPR000910:HMG 
Evalue:-10.7447274948967 
Location:154-220
SequencesProtein: TFAM_HUMAN (246 aa)
mRNA: NM_003201
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 78 residues, 59815181-59815414Exon2: 41 residues, 59815985-59816104Exon3: 25 residues, 59817955-59818026Exon4: 52 residues, 59818435-59818585Exon5: 34 residues, 59820530-59820626Exon6: 21 residues, 59824123-59824180Exon7: 405 residues, 59824693-59825902Exon8: 2 residues, -Jump to TFAM_HUMAN  
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