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0TEP1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionTelomerase protein component 1 (telomerase-associated protein 1) (telomerase protein 1) (p240) (p80 telomerase homolog).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005697 telomerase holoenzyme complex (IDA)
0005515 protein binding (TAS)
0003723 RNA binding (TAS)
0003720 telomerase activity (IDA)
0000067 DNA replication and chromosome cycle (TAS)
0000723 telomere maintenance (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The TROVE (Telomerase.o and Vault) domain is a module of ~300-500 residuesthat is found in TEP1 and Ro60 the protein components of threeribonucleoprotein particles. The TROVE domain is also found in bacterialribonucleoproteins suggesting an ancient origin of these ribonucleoproteins.The TROVE domain can be found associated with other domains.uch as the VWFAdomain.he TEP1 N-terminal domain.he NACHT-NTPase domain.nd WD-40 repeats. The TROVE domain maybe involved in binding the RNA components of the three RNPs.hich aretelomerase RNA. RNA and vault RNA .The TROVE domain contains a few absolutely conserved residues. As none ofthese conserved residues are the polar type of amino acids found in activesites.t seems unlikely that this region has an enzymatic function .
The NACHT domain is a 300 to 400 residue predicted nucleoside triphosphatase (NTPase) domain.hich is found in animal.ungal and bacterial proteins. The NACHT domain has been named after NAIP.IITA.ET-E and TP1. It is found inassociation with other domains.uch as the CARD domain ().heDAPIN domain ().he HEAT repeat ().he WDrepeat ().he leucine-rich repeat (LRR) or the BIR repeat () .The NACHT domain consists of seven distinct conserved motifs.ncluding the ATP/GTPase specific P-loop.he Mg(2+)-binding site (WalkerA and B motifs.espectively) and five more specific motifs. The unique features of the NACHT domain include the prevalence of tiny residues(glycine.lanine or serine) directly C-terminal of the Mg(2+)-coordinating aspartate in the Walker B motif.n place of a second acidic residue prevalentin other NTPases. A second acidic residue is typically found in the NACHT-containing proteins two positions downstream. Furthermore.he distal motif VII contains a conserved pattern of polar.romatic and hydrophobic residues that is not seen in any other NTPase family .
  IPR007111:NACHT nucleoside triphosphatase
This short sequence region is found in four copies at the N terminus of the TEP1 telomerase component. The functional significance of the region is uncertain. However the conservation of two histidines and a cysteine suggests it potentially binds zinc.
  IPR008850:TEP1, N-terminal
WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs.ften terminating in a Trp-Asp (W-D) dipeptide. WD-containing proteins have 4 to 16 repeating units.ll of which are thought to form a circularised beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. The underlying common function of all WD-repeat proteins is coordinating multi-protein complex the repeating units serve as a rigid scaffold for protein interactions. The specificity of the proteins is determined by the sequences outside the repeats themselves. Examples of such complexes are G proteins (beta subunit is a beta-propeller).AFII transcription factor.nd E3 ubiquitin ligase .
  IPR001680:WD-40 repeat
Quinohemoprotein amine dehydrogenase (QHNDH) from Paracoccus denitrificans is a heterotrimer consisting of alpha.eta and gamma chains . The alpha chain has a four-domain structure that includes a dihaem cytochrome c.he beta chain forms a 7-bladed beta-propeller that is part of the enzyme active site.nd the gamma chain contains the redox factor cysteine tryptophylquinone (CTQ).The beta chain of QHNDH structurally resembles the 7-bladed beta propeller of the H chain of the periplasmic quinoprotein methylamine dehydrogenase (MADH).ound in methylotrophic bacteria . MADH is a heterotetramer consisting of two heavy (H) chains and two light (L) chains.nd contains the redox cofactor tryptophan tryptophylquinone (TTQ). There is no similarity between the quinone-containing chains of MAD and QHNDH.The beta-propeller structure found in MAD and QHNDH is similar to the YVTN (Tyr-Val-Thr-Asn) repeat that folds into a beta-propeller found in the N-terminal domain of archaeal surface layer proteins.hich help protect cells from extreme environments .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011044:Quinoprotein amine dehydrogenase, beta chain-like
The WD40 motif is found in a multitude of eukaryotic proteins involved in a variety of cellular processes . Repeated WD40 motifs act as a site for protein-protein interaction.nd proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins. In Arabidopsis sp..everal WD40-containig proteins act as key regulators of plant-specific developmental events. WD40 repeats usually assume a 7-8 bladed beta-propeller fold.ut proteins have been found with 4 to 16 repeated units.The structures of several WD40 repeat-containing proteins have been determined.ncluding the beta-1 subunit of the signal-transducing G protein heterotrimer.he C-terminal domain of yeast Tup1.he C-terminal domain of Groucho/tle1.he Cdc4 propeller domain.he bovine Arp2/3 complex 41 kDa subunit ARPC1.nd actin interacting protein 1. The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
SequencesProtein: TEP1_HUMAN (2627 aa)
mRNA: NM_007110
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 265 residues, 19905765-19906558Exon2: 37 residues, 19906796-19906901Exon3: 79 residues, 19907342-19907575Exon4: 37 residues, 19907672-19907778Exon5: 34 residues, 19909216-19909313Exon6: 50 residues, 19909487-19909631Exon7: 43 residues, 19910731-19910856Exon8: 47 residues, 19911009-19911146Exon9: 46 residues, 19911268-19911401Exon10: 27 residues, 19911505-19911582Exon11: 46 residues, 19911676-19911809Exon12: 38 residues, 19912427-19912535Exon13: 40 residues, 19913753-19913867Exon14: 55 residues, 19914102-19914263Exon15: 73 residues, 19915278-19915491Exon16: 53 residues, 19915598-19915752Exon17: 73 residues, 19916022-19916235Exon18: 54 residues, 19916378-19916534Exon19: 35 residues, 19916752-19916852Exon20: 43 residues, 19916979-19917104Exon21: 43 residues, 19917928-19918052Exon22: 82 residues, 19918233-19918474Exon23: 40 residues, 19918929-19919044Exon24: 31 residues, 19919311-19919400Exon25: 46 residues, 19919551-19919685Exon26: 52 residues, 19919911-19920062Exon27: 46 residues, 19920222-19920355Exon28: 33 residues, 19920621-19920714Exon29: 62 residues, 19921172-19921352Exon30: 54 residues, 19921486-19921643Exon31: 60 residues, 19921741-19921917Exon32: 67 residues, 19922036-19922231Exon33: 41 residues, 19922389-19922507Exon34: 40 residues, 19922598-19922712Exon35: 43 residues, 19922983-19923108Exon36: 42 residues, 19924073-19924194Exon37: 61 residues, 19924445-19924622Exon38: 55 residues, 19925903-19926062Exon39: 22 residues, 19927236-19927296Exon40: 45 residues, 19927608-19927739Exon41: 28 residues, 19928679-19928757Exon42: 55 residues, 19928936-19929095Exon43: 58 residues, 19929597-19929766Exon44: 61 residues, 19933448-19933626Exon45: 32 residues, 19933857-19933948Exon46: 38 residues, 19934619-19934729Exon47: 54 residues, 19938982-19939140Exon48: 43 residues, 19939455-19939580Exon49: 26 residues, 19941375-19941447Exon50: 56 residues, 19941721-19941883Exon51: 56 residues, 19942609-19942771Exon52: 47 residues, 19943449-19943584Exon53: 58 residues, 19944231-19944399Exon54: 199 residues, 19945871-19946462Exon55: 7 residues, 19951403-19951420Exon56: 2 residues, -Jump to TEP1_HUMAN  
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Loci Cluster (Details)Loci: 2822 19598043-19598982 ~-1K 10739(OR4L1)(+)Loci: 4110 19849367-19871297 ~-22K 10743(CCNB1IP1)(-)Loci: 4111 19905765-19951420 ~-46K 10749(TEP1)(-)Loci: 4112 19985056-19993038 ~-8K 10750(OSGEP)(-)Loci: 2823 19993129-19995765 ~-3K 10751(APEX1)(+)Loci: 2821 19414266-19415211 ~-1K 10737(OR4K2)(+)Link out to UCSC