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0TEKT1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTEKT1
DescriptionTektin-1.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Tektin heteropolymers form unique protofilaments of flagellar microtubules. The proteins are predicted to form extended rods composed of 2 alpha-helical segments (~180 residues long) capable of forming coiled coils.nterrupted by non-helical linkers . The 2 segments are similar in sequence.ndicating a gene duplication event. Along each tektin rod.ysteine residues occur with a periodicity of ~8nm.oincident with theaxial repeat of tubulin dimers in microtubules . It is proposed thatthe assembly of tektin heteropolymers produces filaments with repeats of8.6.4.2.0.8 and 96nm.enerating the basis for the complexspatial arrangements of axonemal components .
  IPR000435:Tektin
IPR000435:Tektin 
Evalue:-222.958602905273 
Location:16-399
SequencesProtein: TEKT1_HUMAN (418 aa)
mRNA: NM_053285
Local Annotation
Synapse Ontology
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 85 residues, 6644024-6644277Exon2: 67 residues, 6644789-6644986Exon3: 76 residues, 6656873-6657096Exon4: 50 residues, 6659205-6659349Exon5: 45 residues, 6659876-6660005Exon6: 57 residues, 6663235-6663401Exon7: 71 residues, 6674229-6674436Exon8: 33 residues, 6675691-6675784Exon9: 2 residues, -Jump to TEKT1_HUMAN  
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Loci Cluster (Details)Loci: 4258 6644024-6675784 ~-32K 14997(TEKT1)(-)Loci: 4259 7033935-7063745 ~-30K 15014(DLG4)(-)Loci: 2974 7063876-7069308 ~-5K 15016(ACADVL)(+)Loci: 4260 7084462-7086477 ~-2K 15021(GABARAP)(-)Loci: 2975 7252225-7263903 ~-12K 15047(NLGN2)(+)Loci: 2976 7289129-7301655 ~-13K 15051(CHRNB1)(+)Loci: 2977 7427889-7432228 ~-4K 15066(MPDU1)(+)Loci: 2978 7474184-7477419 ~-3K 15071(SHBG)(+)Loci: 4261 7512446-7531642 ~-19K 15074(TP53)(-)Loci: 4262 7774391-7775983 ~-2K 15094(TRAPPC1)(-)Loci: 2979 7846716-7864382 ~-18K 15097(GUCY2D)(+)Loci: 4263 8004447-8006987 ~-3K 15108(VAMP2)(-)Loci: 2980 8093361-8114528 ~-21K 15119(PFAS)(+)Loci: 2981 8279988-8330396 ~-50K 15135(+)Loci: 2973 6620295-6631688 ~-11K 14996(FBXO39)(+)Link out to UCSC