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0TBG2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTUBG2
DescriptionTubulin gamma-2 chain (gamma-2 tubulin).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005813 centrosome (ISS)
0005737 cytoplasm (ISS)
0000930 gamma-tubulin complex (ISS)
0015630 microtubule cytoskeleton (TAS)
0005827 polar microtubule (ISS)
0005515 protein binding (ISS)
0005200 structural constituent of cytoskeleton (ISS)
0000226 microtubule cytoskeleton organization and b... (ISS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found in all tubulin chains.swell as the bacterial FtsZ family of proteins. These proteinsare involved in polymer formation. Tubulin is the major componentof microtubules.hile FtsZ is the polymer-forming proteinof bacterial cell division.t is part of a ring in the middle of thedividing cell that is required for constriction of cell membrane andcell envelope to yield two daughter cells. FtsZ and tubulin are GTPases.his entry is the GTPase domain.FtsZ can polymerise into tubes.heets.nd rings in vitro and isubiquitous in bacteria and archaea.
  IPR003008:Tubulin/FtsZ, GTPase
This domain is found in the tubulin alpha.eta and gamma chains.swell as the bacterial FtsZ family of proteins. These proteinsare GTPases and are involved in polymer formation. Tubulin is the major componentof microtubules.hile FtsZ is the polymer-forming proteinof bacterial cell division.t is part of a ring in the middle of thedividing cell that is required for constriction of cell membrane andcell envelope to yield two daughter cells. FtsZ can polymerise into tubes.heets.nd rings in vitro and isubiquitous in bacteria and archaea. This is the C-terminal domain.
  IPR008280:Tubulin/FtsZ, C-terminal
Microtubules are polymers of tubulin. dimer of two 55-kDa subunits.esignated alpha and beta . Within the microtubule lattice.lpha-beta heterodimers associate in a head-to-tail fashion.iving rise to microtubule polarity. Fluorescent labelling studies have suggested that tubulin is oriented in microtubules with beta-tubulin toward the plus end . For maximal rate and extent of polymerisation into microtubules.ubulin requires GTP. Two molecules of GTP are bound at different sites.ermed N and E. At the E (Exchangeable) site.TP is hydrolysed during incorporationinto the microtubule. Close to the E site is an invariant region rich in glycine residues.hich is found in both chains and is thought to controlaccess of the nucleotide to its binding site .Most species.xcepting simple eukaryotes.xpress a variety of closely-related alpha- and beta-isotypes. A third family member.amma tubulin.asalso been identified in a number of species. Gamma tubulin is found at microtubule-organising centres.uch as the spindle poles or the centrosome.uggesting that it is involved in minus-end nucleation of microtubule assembly .
  IPR000217:Tubulin
Microtubules are polymers of tubulin. dimer of two 55 kD subunits.esignated alpha and beta . Within the microtubule lattice.lpha-betaheterodimers associate in a head-to-tail fashion.iving rise to microtubule polarity. Fluorescent labelling studies have suggested that tubulin isoriented in microtubules with beta-tubulin toward the plus end . For maximal rate and extent of polymerisation into microtubules.ubulin requires GTP. Two molecules of GTP are bound at different sites.ermed N and E. At the E (Exchangeable) site.TP is hydrolysed during incorporationinto the microtubule. Close to the E site is an invariant region rich in glycine residues.hich is found in both chains and is thought to controlaccess of the nucleotide to its binding site . Most species.xcepting simple eukaryotes.xpress a variety of closely related alpha- and beta-isotypes. A third family member.amma tubulin.asalso been identified in a number of species . Gamma-tubulins constitute a ubiquitous and highly conserved subfamily of the tubulin family. The protein is found at microtubule-organising centres.uch as the spindle poles or the centrosome. It remains associated with the centrosome when microtubules are depolymerised.uggesting that it is an integral component that might play a role in minus-end nucleation of microtubule assembly .
  IPR002454:Gamma tubulin
IPR003008:Tubulin 
Evalue:-97.4436950683594 
Location:46-247IPR008280:Tubulin_C 
Evalue:-59.7958793640137 
Location:249-393IPR002454:GAMMATUBULIN 
Evalue:0 
Location:420-443IPR000217:TUBULIN 
Evalue:0 
Location:11-31
SequencesProtein: TBG2_HUMAN (451 aa)
mRNA: NM_016437
Local Annotation
Synapse Ontology
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 87 residues, 38064836-38065096Exon2: 39 residues, 38065377-38065490Exon3: 58 residues, 38065692-38065860Exon4: 25 residues, 38066182-38066251Exon5: 28 residues, 38068516-38068596Exon6: 44 residues, 38068920-38069047Exon7: 31 residues, 38071019-38071106Exon8: 52 residues, 38071221-38071371Exon9: 53 residues, 38071630-38071783Exon10: 56 residues, 38071866-38072028Exon11: 136 residues, 38072146-38072549Exon12: 2 residues, -Jump to TBG2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4288 37562438-37586822 ~-24K 15872(KCNH4)(-)Loci: 4289 37589603-37590996 ~-1K 15873(HCRT)(-)Loci: 3002 37864387-37928122 ~-64K 15882(ATP6V0A1)(+)Loci: 3003 37941476-37949990 ~-9K 15887(NAGLU)(+)Loci: 3004 38064836-38072549 ~-8K 15898(TUBG2)(+)Loci: 3005 38088157-38105358 ~-17K 15903(CNTNAP1)(+)Loci: 4290 38105819-38150574 ~-45K 15904(EZH1)(-)Loci: 3006 38186221-38202605 ~-16K 15907(WNK4)(+)Loci: 4291 38215677-38229807 ~-14K 15912(BECN1)(-)Loci: 3007 38250134-38256248 ~-6K 15916(AOC2)(+)Loci: 3008 38256726-38263664 ~-7K 15917(AOC3)(+)Loci: 4292 38420147-38427921 ~-8K 15927(VAT1)(-)Loci: 4293 38449839-38530657 ~-81K 15931(BRCA1)(-)Loci: 4287 37530523-37560548 ~-30K 15871(RAB5C)(-)Link out to UCSC