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0TBCB_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCKAP1
DescriptionTubulin-specific chaperone b (tubulin folding cofactor b) (cytoskeleton associated protein 1) (cytoskeleton-associated protein ckapi).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0015630 microtubule cytoskeleton (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Cytoskeleton-associated proteins (CAP) are made of three distinct parts.n N-terminal section that is most probably globular and contains the CAP-Gly domain. large central region predicted to be in an alpha-helical coiled-coil conformation and.inally. short C-terminal globular domain. The CAP-Gly domain is a conserved.lycine-rich domain of about 42 residues found in some CAPs . Proteins known to contain this domain include restin (also known as cytoplasmic linker protein-170 or CLIP-170). 160 kDa protein associated with intermediate filaments and that links endocytic vesicles to microtubules; vertebrate dynactin (150 kDa dynein-associated polypeptide; DAP) and Drosophila glued. major component of activator I; yeast protein BIK1.hich seems to be required for the formation orstabilisation of microtubules during mitosis and for spindle pole body fusion during conjugation; yeast protein NIP100 (NIP80); human protein CKAP1/TFCB; Schizosaccharomyces pombe protein alp11 and Caenorhabditis elegans hypothetical protein F53F4.3. The latter proteins contain a N-terminal ubiquitin domain and a C-terminal CAP-Gly domain. The crystal structure of the CAP-Gly domain of C. elegans F53F4.3 protein.olved by single wavelength sulphur-anomalous phasing.evealed a novel protein fold containing three beta-sheets. The most conserved sequence.KNDG.s located in two consecutive sharp turns on the surface.orming the entrance to a groove. Residues in the groove are highly conserved as measured from the information content of the aligned sequences. The C-terminal tail of another molecule in the crystal is bound in this groove .
  IPR000938:CAP-Gly
IPR000938:CAP_GLY 
Evalue:-38.1366767883301 
Location:161-230
SequencesProtein: TBCB_HUMAN (244 aa)
mRNA: NM_001281
Local Annotation
Synapse Ontology
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 230 residues, 41297727-41298416Exon2: 50 residues, 41298782-41298926Exon3: 34 residues, 41303451-41303548Exon4: 66 residues, 41304268-41304460Exon5: 26 residues, 41308192-41308265Exon6: 95 residues, 41308409-41308689Exon7: 2 residues, -Jump to TBCB_HUMAN  
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Loci Cluster (Details)Loci: 3105 41051240-41062538 ~-11K 18643(APLP1)(+)Loci: 3106 41297727-41308689 ~-11K 18664(CKAP1)(+)Loci: 4386 41008705-41034579 ~-26K 18639(NPHS1)(-)Link out to UCSC