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0TAU_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMAPT
DescriptionMicrotubule-associated protein tau (neurofibrillary tangle protein) (paired helical filament-tau) (phf-tau).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0030424 axon (NAS)
0005829 cytosol (TAS)
0005875 microtubule associated complex (TAS)
0005886 plasma membrane (TAS)
0005200 structural constituent of cytoskeleton (TAS)
0007026 negative regulation of microtubule depolyme... (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Microtubules consist of tubulins as well as a group of additional proteinscollectively known as the Microtubule Associated Proteins (MAP). MAPs havebeen classified into two classes: high molecular weight MAPs and Tauprotein. The Tau proteins promote microtubule assembly and stabilizemicrotubules.The C-terminal region of these proteins contains three or four tandem repeatsof a conserved domain of about thirty amino acid residues which is implicatedin tubulin-binding and which seems to have a stiffening effect on microtubules.
  IPR001084:Tubulin-binding Tau protein
Tau proteins are microtubule-associated proteins that are involved inmicrotubule assembly and stabilisation. They may also play a wider role in cellular shape.otility and signal transduction . Tau mRNA is expressed predominantlyin neurones.nd particularly in their axons. Quite a number of isoformshave been detected.hich in human brain have been shown to arise fromalternative splicing of an mRNA from a single gene located on chromosome 17.The isoforms contain 352-441 amino acid residues. A larger tau isoform hasalso been detected.hich is expressed principally in the peripheral nervoussystem . Each isoform contains a variable number of C-terminal repeatregions that are thought to be responsible for tubulin-binding. The acidic N-terminal region projects from the micro-tubule surface when Tau is bound and may interact with other cytoskeletal elements. The middle region is proline-rich and may be a further binding site. It contains the target sites of many kinases.hosphorylation of this region may result in a change in the conformational state of the protein.nd affect its ability to bind microtubules . Tau does not appear to be an essential protein.ince transgenic micelacking tau appear to develop a normal nervous system with only mildalterations in the structure of certain small-calibre axons . However.t has received much recent attention due to its possible role in theaetiogenesis of a number of human neurodegenerative diseases.ilamentousinclusions containing tau having been found in the brains of patientsdiagnosed with Alzheimers disease.icks disease and progressivesupranuclear palsy. Furthermore.au gene mutations have been found inpatients suffering familial frontotemporal dementia.hich result inabnormal tau protein aggregates forming in the brain tissue .
  IPR002955:Tau protein
IPR001084:Tubulin-binding 
Evalue:-17.1870861053467 
Location:591-621IPR001084:Tubulin-binding 
Evalue:-15.8860569000244 
Location:622-652IPR001084:Tubulin-binding 
Evalue:-14.795880317688 
Location:559-590IPR001084:Tubulin-binding 
Evalue:-14.795880317688 
Location:653-684IPR002955:TAUPROTEIN 
Evalue:0 
Location:466-477IPR002955:TAUPROTEIN 
Evalue:0 
Location:478-487IPR002955:TAUPROTEIN 
Evalue:0 
Location:529-537IPR002955:TAUPROTEIN 
Evalue:0 
Location:502-509IPR002955:TAUPROTEIN 
Evalue:0 
Location:538-545
SequencesProtein: TAU_HUMAN (757 aa)
mRNA: NM_016835
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
?
sdb:0265 cAMP mediated STP  (Evidence:keywords)
the mechanism by which the restiong potential is held.
sdb:0288 maintain membrane potential  (Evidence:keywords)
KO assignmentK04380
  Level 3 annotation:
    microtubule-associated protein tau
  Level 2 annotation:
    MAPK signaling pathway
    Alzheimer's disease
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 75 residues, 41327623-41327846Exon2: 52 residues, 41395522-41395672Exon3: 31 residues, 41405060-41405147Exon4: 31 residues, 41407586-41407673Exon5: 24 residues, 41411576-41411642Exon6: 253 residues, 41416380-41417133Exon7: 20 residues, 41420242-41420298Exon8: 68 residues, 41423080-41423278Exon9: 44 residues, 41424662-41424789Exon10: 90 residues, 41429601-41429867Exon11: 33 residues, 41443512-41443605Exon12: 29 residues, 41447445-41447527Exon13: 39 residues, 41451830-41451943Exon14: 1461 residues, 41457166-41461544Exon15: 2 residues, -Jump to TAU_HUMANExon1: 130 residues, 41432482-41432869Exon2: 2 residues, -Jump to STH_HUMAN  
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