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0SYUG_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSNCG
DescriptionGamma-synuclein (persyn) (breast cancer-specific gene 1 protein) (synoretin) (sr).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains assigned to SynO:
Synucleins are small.oluble proteins expressed primarily in neural tissue and in certain tumors . The family includes three known proteins: alpha-synuclein.eta-synuclein.nd gamma-synuclein. All synucleins have in common a highly conserved alpha-helical lipid-binding motif with similarity to the class-A2 lipid-binding domains of the exchangeable apolipoproteins .Synuclein family members are not found outside vertebrates.lthough they have some conserved structural similarity with plant late-embryo-abundant proteins. The alpha- and beta-synuclein proteins are found primarily in brain tissue.here they are seen mainly in presynaptic terminals . The gamma-synuclein protein is found primarily in the peripheral nervous system and retina.ut its expression in breast tumors is a marker for tumor progression . Normal cellular functions have not been determined for any of the synuclein proteins.lthough some data suggest a role in the regulation of membrane stability and/or turnover. Mutations in alpha-synuclein are associated with rare familial cases of early-onset Parkinsons disease.nd the protein accumulates abnormally in Parkinsons disease.lzheimers disease.nd several other neurodegenerative illnesses .
  IPR001058:Synuclein
InterPro domains unassigned to SynO:
Synucleins are small.oluble proteins expressed primarily in neural tissue and in certain tumors . The family includes three known proteins: alpha-synuclein.eta-synuclein.nd gamma-synuclein. All synucleins have in common a highly conserved alpha-helical lipid-binding motif with similarity to the class-A2 lipid-binding domains of the exchangeable apolipoproteins .Synuclein family members are not found outside vertebrates.lthough they have some conserved structural similarity with plant late-embryo-abundant proteins. The alpha- and beta-synuclein proteins are found primarily in brain tissue.here they are seen mainly in presynaptic terminals . The gamma-synuclein protein is found primarily in the peripheral nervous system and retina.ut its expression in breast tumors is a marker for tumor progression . Normal cellular functions have not been determined for any of the synuclein proteins.lthough some data suggest a role in the regulation of membrane stability and/or turnover. Mutations in alpha-synuclein are associated with rare familial cases of early-onset Parkinsons disease.nd the protein accumulates abnormally in Parkinsons disease.lzheimers disease.nd several other neurodegenerative illnesses . As with other synucleins.amma-synuclein.r persyn.s believed to beinvolved in the pathogenesis of human neurodegenerative diseases . Persyn influences neurofilament network integrity .
  IPR002462:Gamma-synuclein
IPR001058:Synuclein 
Evalue:-64.4685211181641 
Location:1-126
SequencesProtein: SYUG_HUMAN (127 aa)
mRNA: NM_003087
Local Annotation
Synapse Ontology
all
sdb:0004 Presynaptic compartment  (Evidence:keywords,domains)
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords,domains)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords,domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 55 residues, 88708392-88708555Exon2: 16 residues, 88709369-88709411Exon3: 44 residues, 88709737-88709865Exon4: 26 residues, 88712340-88712412Exon5: 100 residues, 88712701-88712995Exon6: 2 residues, -Jump to SYUG_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3904 88800222-88844603 ~-44K 5265(GLUD1)(-)Loci: 2624 88708392-88712995 ~-5K 5262(SNCG)(+)Link out to UCSC