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0SYUB_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSNCB
DescriptionBeta-synuclein.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004859 phospholipase inhibitor activity (TAS)
Domain Architecture (Details)
InterPro domains assigned to SynO:
Synucleins are small.oluble proteins expressed primarily in neural tissue and in certain tumors . The family includes three known proteins: alpha-synuclein.eta-synuclein.nd gamma-synuclein. All synucleins have in common a highly conserved alpha-helical lipid-binding motif with similarity to the class-A2 lipid-binding domains of the exchangeable apolipoproteins .Synuclein family members are not found outside vertebrates.lthough they have some conserved structural similarity with plant late-embryo-abundant proteins. The alpha- and beta-synuclein proteins are found primarily in brain tissue.here they are seen mainly in presynaptic terminals . The gamma-synuclein protein is found primarily in the peripheral nervous system and retina.ut its expression in breast tumors is a marker for tumor progression . Normal cellular functions have not been determined for any of the synuclein proteins.lthough some data suggest a role in the regulation of membrane stability and/or turnover. Mutations in alpha-synuclein are associated with rare familial cases of early-onset Parkinsons disease.nd the protein accumulates abnormally in Parkinsons disease.lzheimers disease.nd several other neurodegenerative illnesses .
  IPR001058:Synuclein
InterPro domains unassigned to SynO:
Synucleins are small.oluble proteins expressed primarily in neural tissue and in certain tumors . The family includes three known proteins: alpha-synuclein.eta-synuclein.nd gamma-synuclein. All synucleins have in common a highly conserved alpha-helical lipid-binding motif with similarity to the class-A2 lipid-binding domains of the exchangeable apolipoproteins .Synuclein family members are not found outside vertebrates.lthough they have some conserved structural similarity with plant late-embryo-abundant proteins. The alpha- and beta-synuclein proteins are found primarily in brain tissue.here they are seen mainly in presynaptic terminals . The gamma-synuclein protein is found primarily in the peripheral nervous system and retina.ut its expression in breast tumors is a marker for tumor progression . Normal cellular functions have not been determined for any of the synuclein proteins.lthough some data suggest a role in the regulation of membrane stability and/or turnover. Mutations in alpha-synuclein are associated with rare familial cases of early-onset Parkinsons disease.nd the protein accumulates abnormally in Parkinsons disease.lzheimers disease.nd several other neurodegenerative illnesses . Beta-synuclein.lso known as PNP 14.s expressed in the brain.pecifically in synapses aroundneurons.ut not in glial cells. The protein.hich has been designateda phosphoneuroprotein.as been found to be phosphorylated in vitro and invivo . It is believed that the physiological functions of beta-synuclein may be controlled by the phosphorylation reaction.
  IPR002461:Beta-synuclein
IPR001058:Synuclein 
Evalue:-68.3098068237305 
Location:1-126
SequencesProtein: SYUB_HUMAN (134 aa)
mRNA: NM_001001502
Local Annotation
Synapse Ontology
all
sdb:0004 Presynaptic compartment  (Evidence:keywords,domains)
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords,domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 212 residues, 175979816-175980450Exon2: 32 residues, 175980820-175980910Exon3: 41 residues, 175986004-175986123Exon4: 16 residues, 175986326-175986368Exon5: 45 residues, 175989140-175989270Exon6: 54 residues, 175989415-175989572Exon7: 94 residues, 175989886-175990163Exon8: 2 residues, -Jump to SYUB_HUMAN  
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