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0SYUA_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSNCA
DescriptionAlpha-synuclein (non-a beta component of ad amyloid) (non-a4 component of amyloid precursor) (nacp).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (TAS)
0005515 protein binding (IPI)
0006916 anti-apoptosis (TAS)
0007417 central nervous system development (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Synucleins are small.oluble proteins expressed primarily in neural tissue and in certain tumors . The family includes three known proteins: alpha-synuclein.eta-synuclein.nd gamma-synuclein. All synucleins have in common a highly conserved alpha-helical lipid-binding motif with similarity to the class-A2 lipid-binding domains of the exchangeable apolipoproteins .Synuclein family members are not found outside vertebrates.lthough they have some conserved structural similarity with plant late-embryo-abundant proteins. The alpha- and beta-synuclein proteins are found primarily in brain tissue.here they are seen mainly in presynaptic terminals . The gamma-synuclein protein is found primarily in the peripheral nervous system and retina.ut its expression in breast tumors is a marker for tumor progression . Normal cellular functions have not been determined for any of the synuclein proteins.lthough some data suggest a role in the regulation of membrane stability and/or turnover. Mutations in alpha-synuclein are associated with rare familial cases of early-onset Parkinsons disease.nd the protein accumulates abnormally in Parkinsons disease.lzheimers disease.nd several other neurodegenerative illnesses .
  IPR001058:Synuclein
InterPro domains unassigned to SynO:
Synucleins are small.oluble proteins expressed primarily in neural tissue and in certain tumors . The family includes three known proteins: alpha-synuclein.eta-synuclein.nd gamma-synuclein. All synucleins have in common a highly conserved alpha-helical lipid-binding motif with similarity to the class-A2 lipid-binding domains of the exchangeable apolipoproteins .Synuclein family members are not found outside vertebrates.lthough they have some conserved structural similarity with plant late-embryo-abundant proteins. The alpha- and beta-synuclein proteins are found primarily in brain tissue.here they are seen mainly in presynaptic terminals . The gamma-synuclein protein is found primarily in the peripheral nervous system and retina.ut its expression in breast tumors is a marker for tumor progression . Normal cellular functions have not been determined for any of the synuclein proteins.lthough some data suggest a role in the regulation of membrane stability and/or turnover. Mutations in alpha-synuclein are associated with rare familial cases of early-onset Parkinsons disease.nd the protein accumulates abnormally in Parkinsons disease.lzheimers disease.nd several other neurodegenerative illnesses . Synelfin from the zebra finch is a homolog of the human alpha-synuclein and may serve a novel function critical to the regulation of vertebrate neural plasticity . It is regulated during the critical period for song learning.
  IPR002460:Alpha-synuclein
IPR001058:Synuclein 
Evalue:-73 
Location:1-132
SequencesProtein: SYUA_HUMAN (140 aa)
mRNA: NM_000345
Local Annotation
Synapse Ontology
all
sdb:0004 Presynaptic compartment  (Evidence:keywords,domains)
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords,domains)
The directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.
sdb:0057 axon transport  (Evidence:keywords,domains)
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords,domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 370 residues, 90865727-90866834Exon2: 30 residues, 90869367-90869451Exon3: 49 residues, 90962419-90962562Exon4: 16 residues, 90968316-90968358Exon5: 50 residues, 90975720-90975866Exon6: 9 residues, 90977135-90977156Exon7: 2 residues, -Jump to SYUA_HUMAN  
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