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0SYTL2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSYTL2
DescriptionSynaptotagmin-like protein 2 (exophilin-4).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0019897 extrinsic to plasma membrane (ISS)
0042470 melanosome (ISS)
0005624 membrane fraction (ISS)
0042043 neurexin binding (ISS)
0016192 vesicle-mediated transport (ISS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The C2 domain is a Ca2+-dependent membrane-targeting module found in many cellular proteins involved in signal transduction or membrane trafficking. C2 domains are unique among membrane targeting domains in that they show wide range of lipid selectivity for the major components of cell membranes.ncluding phosphatidylserine and phosphatidylcholine. This C2 domain is about 116 amino-acid residues and is located between the two copies ofthe C1 domain in Protein Kinase C (that bind phorbol esters and diacylglycerol) (see )and the protein kinase catalytic domain (see ). Regions withsignificant homology to the C2-domain have been found in many proteins.The C2 domain is thought to be involved in calcium-dependent phospholipidbinding and in membrane targetting processes such as subcellular localisation. The 3D structure of theC2 domain of synaptotagmin has been reported.he domain forms an eight-stranded beta sandwich constructed around a conserved 4-stranded motif.esignated a C2 key . Calcium binds ina cup-shaped depression formed by the N- and C-terminal loops of theC2-key motif. Structural analyses of several C2 domains have shown them to consist of similar ternary structures in which three Ca2+-binding loops are located at the end of an 8 stranded antiparallel beta sandwich.
  IPR000008:C2 calcium-dependent membrane targeting
The Ca2+-dependent.ipid-binding domain (CaLB) has been identified in a number of proteins.or example the amino-terminal.38 amino acid C2 domain of cytosolic phospholipase A2 (cPLA2-C2) which mediates an initial step in the production of lipid mediators of inflammation: the Ca2+-dependent translocation of the enzyme to intracellular membranes with subsequent liberation of arachidonic acid. The domain is composed of eight antiparallel beta-strands with six interconnecting loops that fits the "type II" topology for C2 domains. The structure has been identified as a beta-sandwich in the "Greek key" motif .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008973:C2 calcium/lipid-binding region, CaLB
IPR000008:C2 
Evalue:-28.1611499786377 
Location:606-695IPR000008:C2 
Evalue:-21.8239078521729 
Location:755-842IPR010911:RABBD 
Evalue:0 
Location:1-42
SequencesProtein: SYTL2_HUMAN (895 aa)
mRNA: NM_032943
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords,domains)
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords,domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:keywords,domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 373 residues, 85082914-85084031Exon2: 70 residues, 85084873-85085079Exon3: 35 residues, 85086669-85086769Exon4: 28 residues, 85089205-85089284Exon5: 59 residues, 85093548-85093719Exon6: 36 residues, 85096119-85096222Exon7: 58 residues, 85098021-85098191Exon8: 33 residues, 85103103-85103198Exon9: 18 residues, 85106173-85106221Exon10: 20 residues, 85107480-85107534Exon11: 36 residues, 85109548-85109650Exon12: 26 residues, 85116586-85116658Exon13: 270 residues, 85122629-85123433Exon14: 39 residues, 85125191-85125303Exon15: 29 residues, 85126265-85126347Exon16: 47 residues, 85134327-85134463Exon17: 52 residues, 85136962-85137114Exon18: 127 residues, 85146315-85146692Exon19: 2 residues, -Jump to SYTL2_HUMAN  
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Loci Cluster (Details)Loci: 3981 85346133-85457756 ~-112K 7529(PICALM)(-)Loci: 3980 85082914-85146692 ~-64K 7513(SYTL2)(-)Link out to UCSC