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0SYPL2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSYPL2
DescriptionSynaptophysin-like protein 2.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains assigned to SynO:
Synaptophysin and synaptoporin are related glycoproteins: they are the major integral membrane proteins of a certain class of small neurosecretory vesicles.lthough they may also be found in vesicles of various non-endocrine cells . The polypeptide chain spans the membrane four times and possibly acts as an ion or solute channel.
  IPR001285:Synaptophysin/synaptoporin
InterPro domains unassigned to SynO:
MARVEL domain is often found in lipid-associating proteins - such as Occludin and MAL family proteins . It may be part of the machinery of membrane apposition events.uch as transport vesicle biogenesis.
  IPR008253:Marvel
IPR008253:MARVEL 
Evalue:-60.7212448120117 
Location:30-238
SequencesProtein: SYPL2_HUMAN (272 aa)
mRNA: AK131459
Local Annotation
Synapse Ontology
Penetrating at least one phospholipid bilayer of a synaptic vesicle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
sdb:0078 integral to synaptic vesicle membrane proteins  (Evidence:keywords,domains)
proteins that help to traffick the vesicle, such as synaptobrevin/Vamp, synaptotagmin, Rab3-rabphilin complex.
sdb:0097 vesicle trafficking protein  (Evidence:keywords,domains)
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords,domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:keywords,domains)
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:keywords,domains)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords,domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 141 residues, 109810622-109811042Exon2: 27 residues, 109811203-109811278Exon3: 43 residues, 109819725-109819850Exon4: 69 residues, 109820920-109821122Exon5: 1440 residues, 109821962-109826277Exon6: 2 residues, -Jump to SYPL2_HUMAN  
Loci Cluster (Details)Loci: 2532 109221349-109274541 ~-53K 2049(+)Loci: 2533 109594163-109619895 ~-26K 2068(CELSR2)(+)Loci: 3813 109653714-109742086 ~-88K 2077(SORT1)(-)Loci: 2534 109810622-109826277 ~-16K 2079(SYPL2)(+)Loci: 3814 109850969-109853827 ~-3K 2087(AMIGO1)(-)Loci: 2531 109090830-109153671 ~-63K 2044(STXBP3)(+)Link out to UCSC