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0SYNPR_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains assigned to SynO:
Synaptophysin and synaptoporin are related glycoproteins: they are the major integral membrane proteins of a certain class of small neurosecretory vesicles.lthough they may also be found in vesicles of various non-endocrine cells . The polypeptide chain spans the membrane four times and possibly acts as an ion or solute channel.
InterPro domains unassigned to SynO:
MARVEL domain is often found in lipid-associating proteins - such as Occludin and MAL family proteins . It may be part of the machinery of membrane apposition events.uch as transport vesicle biogenesis.
SequencesProtein: SYNPR_HUMAN (265 aa)
mRNA: AK122831 NM_144642
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords,domains)
Penetrating at least one phospholipid bilayer of a synaptic vesicle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
sdb:0078 integral to synaptic vesicle membrane proteins  (Evidence:keywords,domains)
proteins that help to traffick the vesicle, such as synaptobrevin/Vamp, synaptotagmin, Rab3-rabphilin complex.
sdb:0097 vesicle trafficking protein  (Evidence:keywords,domains)
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords,domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:keywords,domains)
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:keywords,domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 46 residues, 63404048-63404185Exon2: 13 residues, 63406259-63406292Exon3: 43 residues, 63441547-63441672Exon4: 68 residues, 63517258-63517457Exon5: 66 residues, 63569840-63570032Exon6: 567 residues, 63575939-63577636Exon7: 2 residues, -Jump to SYNPR_HUMANExon1: 41 residues, 63404063-63404185Exon2: 43 residues, 63441547-63441672Exon3: 68 residues, 63517258-63517457Exon4: 66 residues, 63569840-63570032Exon5: 567 residues, 63575939-63577636Exon6: 2 residues, -Jump to SYNPR_HUMAN  
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