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0SYNP2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionSynaptopodin-2 (myopodin) (genethonin 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
PDZ domains are found in diverse signaling proteins in bacteria.easts.lants.nsects and vertebrates . PDZ domains can occur in one or multiple copies and are nearly always found in cytoplasmic proteins. They bind either the carboxyl-terminal sequences of proteins or internal peptide sequences . In most cases.nteraction between a PDZ domain and its target is constitutive.ith a binding affinity of 1 to 10 ┬ÁM. However.gonist-dependent activation of cell surface receptors is sometimes required to promote interaction with a PDZ protein. PDZ domain proteins are frequently associated with the plasma membrane. compartment where high concentrations of phosphatidylinositol 4.-bisphosphate (PIP2) are found. Direct interaction between PIP2 and a subset of class II PDZ domains (syntenin.ASK.iam-1) has been demonstrated. PDZ domains consist of 80 to 90 amino acids comprising six beta-strands (betaA to betaF) and two alpha-helices. and B.ompactly arranged in a globular structure. Peptide binding of the ligand takes place in an elongated surface groove as an antiparallel beta-strand interacts with the betaB strand and the B helix. The structure of PDZ domains allows binding to a free carboxylate group at the end of a peptide through a carboxylate-binding loop between the betaA and betaB strands.
SequencesProtein: SYNP2_HUMAN (1093 aa)
mRNA: AL833294 NM_133477
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
sdb:0329 actin in synaptic vesicle cycling  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 101 residues, 120029443-120029744Exon2: 52 residues, 120164032-120164184Exon3: 272 residues, 120167229-120168041Exon4: 729 residues, 120170447-120172630Exon5: 356 residues, 120198003-120199067Exon6: 922 residues, 120199079-120201841Exon7: 2 residues, -Jump to SYNP2_HUMANExon1: 96 residues, 120029457-120029744Exon2: 52 residues, 120164032-120164184Exon3: 272 residues, 120167229-120168041Exon4: 1993 residues, 120170447-120176422Exon5: 2 residues, -Jump to SYNP2_HUMAN  
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