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0SYNJ1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSYNJ1
DescriptionSynaptojanin-1 (ec 3.1.3.36) (synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004445 inositol-polyphosphate 5-phosphatase activity (TAS)
0006796 phosphate metabolism (TAS)
0048488 synaptic vesicle endocytosis (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found in diverse proteins homologous to inositol monophosphatase . These proteins are Mg2+-dependent/Li+-sensitive phosphatases. That catalyse a variety of reactions.
  IPR000300:Inositol polyphosphate related phosphatase
Synaptic vesicles are recycled with remarkable speed and precision in nerve terminals. A major recycling pathway involves clathrin-mediated endocytosis at endocytic zones located around sites of release. Different accessory proteins linked to this pathway have been shown to alter the shape and composition of lipid membranes.o modify membrane-coat protein interactions.nd to influence actin polymerization. These include the GTPase dynamin.he lysophosphatidic acid acyl transferase endophilin.nd the phosphoinositide phosphatase synaptojanin . The recessive suppressor of secretory defect in yeast Golgi and yeastactin function belongs to this family. This protein may be involved in the coordination of the activities of the secretory pathway and the actin cytoskeleton.Human synaptojanin which may be localised on coated endocytic intermediates in nerve terminals also belongs to this family.
  IPR002013:Synaptojanin, N-terminal
This domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling . Proteins this domain is found in include: AP endonuclease proteins ().Nase I proteins ().ynaptojanin an inositol-1..-trisphosphate phosphatase () and Sphingomyelinase ().
  IPR005135:Endonuclease/exonuclease/phosphatase
This entry represents nucleotide-binding domains with an alpha-beta plait structure.hich consists of either a ferredoxin-like (beta-alpha-beta)2 fold.uch as that found in RNA-binding domains of various ribonucleoproteins or in viral DNA-binding domains . or a beta-(alpha)-beta-alpha-beta(2) fold.uch as that found in the ribosomal protein L23 .
  IPR012677:Nucleotide-binding, alpha-beta plait
IPR000300:IPPc 
Evalue:-174.275724130399 
Location:531-874IPR002013:Syja_N 
Evalue:-151.22184753418 
Location:59-347IPR000504:RRM 
Evalue:0 
Location:902-971
SequencesProtein: SYNJ1_HUMAN (1575 aa)
mRNA: AF009039 NM_003895
Local Annotation
Synapse Ontology
A clathrin coat found on a synaptic vesicle.
sdb:0076 clathrin coat of synaptic vesicle  (Evidence:keywords)
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords)
KO assignmentK01099
  Level 3 annotation:
    phosphatidylinositol-bisphosphatase
  Level 2 annotation:
    Inositol phosphate metabolism
    Phosphatidylinositol signaling system
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1014 residues, 32922943-32925982Exon2: 74 residues, 32933088-32933306Exon3: 38 residues, 32933851-32933960Exon4: 25 residues, 32936076-32936147Exon5: 15 residues, 32936275-32936314Exon6: 18 residues, 32937590-32937638Exon7: 15 residues, 32939148-32939187Exon8: 50 residues, 32939826-32939970Exon9: 72 residues, 32940573-32940783Exon10: 56 residues, 32944364-32944527Exon11: 28 residues, 32947468-32947547Exon12: 74 residues, 32950867-32951083Exon13: 41 residues, 32951183-32951301Exon14: 54 residues, 32951896-32952053Exon15: 55 residues, 32959093-32959252Exon16: 66 residues, 32960123-32960316Exon17: 49 residues, 32960613-32960754Exon18: 30 residues, 32964468-32964553Exon19: 66 residues, 32967520-32967712Exon20: 10 residues, 32970512-32970536Exon21: 54 residues, 32972825-32972982Exon22: 53 residues, 32975676-32975829Exon23: 29 residues, 32978218-32978300Exon24: 58 residues, 32979928-32980098Exon25: 34 residues, 32981158-32981255Exon26: 22 residues, 32982486-32982548Exon27: 30 residues, 32988408-32988492Exon28: 77 residues, 32989237-32989463Exon29: 91 residues, 32994018-32994286Exon30: 31 residues, 32996141-32996228Exon31: 50 residues, 33020953-33021099Exon32: 9 residues, 33022127-33022148Exon33: 2 residues, -Jump to SYNJ1_HUMANExon1: 271 residues, 32925170-32925982Exon2: 10 residues, 32929041-32929065Exon3: 74 residues, 32933088-32933306Exon4: 38 residues, 32933851-32933960Exon5: 25 residues, 32936076-32936147Exon6: 15 residues, 32936275-32936314Exon7: 18 residues, 32937590-32937638Exon8: 15 residues, 32939148-32939187Exon9: 50 residues, 32939826-32939970Exon10: 72 residues, 32940573-32940783Exon11: 56 residues, 32944364-32944527Exon12: 28 residues, 32947468-32947547Exon13: 74 residues, 32950867-32951083Exon14: 41 residues, 32951183-32951301Exon15: 54 residues, 32951896-32952053Exon16: 55 residues, 32959093-32959252Exon17: 66 residues, 32960123-32960316Exon18: 49 residues, 32960613-32960754Exon19: 30 residues, 32964468-32964553Exon20: 66 residues, 32967520-32967712Exon21: 10 residues, 32970512-32970536Exon22: 54 residues, 32972825-32972982Exon23: 53 residues, 32975676-32975829Exon24: 29 residues, 32978218-32978300Exon25: 58 residues, 32979928-32980098Exon26: 34 residues, 32981158-32981255Exon27: 22 residues, 32982486-32982548Exon28: 30 residues, 32988408-32988492Exon29: 77 residues, 32989237-32989463Exon30: 91 residues, 32994018-32994286Exon31: 31 residues, 32996141-32996228Exon32: 50 residues, 33020953-33021099Exon33: 9 residues, 33022127-33022148Exon34: 2 residues, -Jump to SYNJ1_HUMAN  
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Loci Cluster (Details)Loci: 3285 33320108-33323370 ~-3K 23762(OLIG2)(+)Loci: 4548 32922943-33022148 ~-99K 23751(SYNJ1)(-)Link out to UCSC