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0SYNE2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSYNE2
DescriptionNesprin-2 (nuclear envelope spectrin repeat protein 2) (syne-2) (synaptic nuclear envelope protein 2) (nucleus and actin connecting element protein) (nuance protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The calponin homology domain (also known as CH-domain) is a superfamily of actin-binding domains found in both cytoskeletal proteins and signal transduction proteins . It comprises the following groups of actin-binding domains:Actinin-type (including spectrin.imbrin.BP-280) (see ).Calponin-type (see ).A comprehensive review of proteins containing this type of actin-binding domains is given in .The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity . Most proteins have two copies of the CH domain.owever some proteins such as calponin and the human vav proto-oncogene () have only a single copy. The structure of an example CH-domain has recently been solved .
  IPR001715:Calponin-like actin-binding
Spectrin repeats are found in several proteins involved incytoskeletal structure. These include spectrin.lpha-actininand dystrophin. The spectrin repeat forms athree helix bundle. The second helix is interrupted by prolinein some sequences. The repeats are defined by a characteristictryptophan (W) residue at position 17 in helix A and a leucine(L) at 2 residues from the carboxyl end of helix C.
  IPR002017:Spectrin repeat
This protein has been called NSP4.SP5.S28.nd NCVP5. The final steps in the assembly of rotavirus occur in the lumen of the endoplasmic reticulum (ER). Targeting of the immature inner capsid particle (ICP) to this compartment is mediated by the cytoplasmic tail of NSP4.ocated in the ER membrane .
  IPR002107:Rotavirus non-structural protein
IPR001715:CH 
Evalue:-31.1487407684326 
Location:182-286IPR001715:CH 
Evalue:-21.6575775146484 
Location:32-136IPR002017:Spectrin 
Evalue:-11.958607673645 
Location:6551-6658IPR002017:SPEC 
Evalue:-11.0268721464003 
Location:6025-6132IPR002017:SPEC 
Evalue:-10.5228787452803 
Location:6139-6241IPR002017:SPEC 
Evalue:-9.31875876262441 
Location:5920-6018IPR002017:SPEC 
Evalue:-9.2839966563652 
Location:6248-6348IPR002017:SPEC 
Evalue:-4.74472749489669 
Location:4947-5052IPR002017:Spectrin 
Evalue:-4.17392539978027 
Location:5178-5274IPR002017:SPEC 
Evalue:-3.18708664335714 
Location:2730-2830IPR002017:SPEC 
Evalue:-2.95860731484177 
Location:5062-5166IPR002017:SPEC 
Evalue:-1.14266750356873 
Location:6664-6768IPR002017:SPEC 
Evalue:-0.823908740944319 
Location:5596-5696IPR002017:SPEC 
Evalue:-0.214670164989233 
Location:5813-5913IPR002017:SPEC 
Evalue:-0.136677139879544 
Location:2252-2354IPR002017:SPEC 
Evalue:-0.0915149811213502 
Location:5279-5381IPR002017:SPEC 
Evalue:-0.0362121726544447 
Location:4841-4940IPR012315:KASH 
Evalue:0 
Location:6826-6885IPR002107:Rota_NSP4 
Evalue:0 
Location:0-0IPR002017:SPEC 
Evalue:0.477121254719662 
Location:2044-2141IPR002017:SPEC 
Evalue:0.518513939877887 
Location:3686-3781IPR002017:SPEC 
Evalue:0.556302500767287 
Location:1437-1531
SequencesProtein: SYNE2_HUMAN (6885 aa)
mRNA: AF435011 AF495911 NM_015180
Local Annotation
Synapse Ontology
A dendritic spine is a mushroom-shaped bud that protrudes from a dendrite and forms one half of a synapse, especially in synapses of the cortex. The dendrites of cortical neurons typically are densely covered with such spines, which enable single cells to receive input from thousands of others.
sdb:0134 dendritic spine  (Evidence:keywords)
cytoskeleton filaments is one kind of structural components to maintain synapse morphology and bear the related function which is connected with the synaptic morphology.
sdb:0280 cytoskeletal filaments  (Evidence:keywords)
the mechanism by which the restiong potential is held.
sdb:0288 maintain membrane potential  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 54 residues, 63389453-63389614Exon2: 45 residues, 63445568-63445698Exon3: 22 residues, 63477084-63477146Exon4: 34 residues, 63478165-63478261Exon5: 28 residues, 63478355-63478433Exon6: 33 residues, 63478521-63478614Exon7: 62 residues, 63486295-63486477Exon8: 67 residues, 63491189-63491386Exon9: 35 residues, 63497995-63498096Exon10: 36 residues, 63500369-63500471Exon11: 48 residues, 63504179-63504317Exon12: 57 residues, 63513033-63513198Exon13: 39 residues, 63514375-63514488Exon14: 56 residues, 63515322-63515485Exon15: 28 residues, 63517124-63517203Exon16: 64 residues, 63517456-63517644Exon17: 57 residues, 63519100-63519265Exon18: 52 residues, 63520207-63520357Exon19: 56 residues, 63522926-63523088Exon20: 55 residues, 63526881-63527040Exon21: 60 residues, 63527412-63527586Exon22: 47 residues, 63530305-63530440Exon23: 55 residues, 63531514-63531673Exon24: 72 residues, 63533417-63533629Exon25: 32 residues, 63533771-63533862Exon26: 38 residues, 63534689-63534799Exon27: 44 residues, 63535384-63535511Exon28: 54 residues, 63537032-63537190Exon29: 51 residues, 63538404-63538552Exon30: 205 residues, 63539190-63539801Exon31: 62 residues, 63543513-63543693Exon32: 52 residues, 63546436-63546587Exon33: 55 residues, 63552943-63553102Exon34: 56 residues, 63554065-63554227Exon35: 36 residues, 63556462-63556564Exon36: 69 residues, 63557785-63557986Exon37: 59 residues, 63558327-63558499Exon38: 39 residues, 63559221-63559334Exon39: 69 residues, 63560727-63560930Exon40: 42 residues, 63561382-63561502Exon41: 99 residues, 63561600-63561892Exon42: 52 residues, 63563049-63563201Exon43: 105 residues, 63563954-63564264Exon44: 57 residues, 63566365-63566530Exon45: 116 residues, 63567486-63567828Exon46: 54 residues, 63584470-63584626Exon47: 90 residues, 63586081-63586347Exon48: 702 residues, 63588027-63590128Exon49: 109 residues, 63592414-63592737Exon50: 50 residues, 63599221-63599366Exon51: 75 residues, 63601902-63602121Exon52: 90 residues, 63607115-63607381Exon53: 58 residues, 63610438-63610607Exon54: 54 residues, 63612415-63612571Exon55: 49 residues, 63614936-63615077Exon56: 63 residues, 63616926-63617109Exon57: 48 residues, 63617913-63618051Exon58: 64 residues, 63624141-63624327Exon59: 43 residues, 63626044-63626167Exon60: 63 residues, 63627336-63627519Exon61: 46 residues, 63629819-63629951Exon62: 68 residues, 63634419-63634617Exon63: 27 residues, 63635217-63635292Exon64: 39 residues, 63638402-63638513Exon65: 41 residues, 63643961-63644078Exon66: 79 residues, 63649811-63650042Exon67: 63 residues, 63655897-63656080Exon68: 47 residues, 63657397-63657532Exon69: 42 residues, 63658482-63658604Exon70: 49 residues, 63658756-63658898Exon71: 46 residues, 63661549-63661681Exon72: 53 residues, 63662797-63662950Exon73: 72 residues, 63663068-63663278Exon74: 36 residues, 63664922-63665024Exon75: 42 residues, 63666252-63666372Exon76: 69 residues, 63666518-63666719Exon77: 60 residues, 63668735-63668909Exon78: 46 residues, 63670539-63670671Exon79: 67 residues, 63674257-63674454Exon80: 46 residues, 63676411-63676544Exon81: 63 residues, 63677811-63677994Exon82: 51 residues, 63678412-63678559Exon83: 61 residues, 63680242-63680419Exon84: 54 residues, 63682538-63682694Exon85: 53 residues, 63689034-63689187Exon86: 59 residues, 63695095-63695266Exon87: 45 residues, 63695782-63695913Exon88: 70 residues, 63698542-63698747Exon89: 62 residues, 63699872-63700052Exon90: 44 residues, 63701755-63701881Exon91: 53 residues, 63703703-63703858Exon92: 50 residues, 63703965-63704110Exon93: 33 residues, 63705347-63705442Exon94: 80 residues, 63706698-63706933Exon95: 67 residues, 63711414-63711609Exon96: 44 residues, 63713828-63713954Exon97: 54 residues, 63722894-63723050Exon98: 55 residues, 63725020-63725179Exon99: 57 residues, 63726541-63726708Exon100: 56 residues, 63739271-63739434Exon101: 64 residues, 63745228-63745416Exon102: 52 residues, 63745898-63746049Exon103: 63 residues, 63746412-63746595Exon104: 48 residues, 63748431-63748569Exon105: 67 residues, 63749281-63749476Exon106: 94 residues, 63750664-63750941Exon107: 48 residues, 63752718-63752858Exon108: 40 residues, 63754868-63754983Exon109: 69 residues, 63755678-63755881Exon110: 69 residues, 63756907-63757108Exon111: 45 residues, 63758046-63758175Exon112: 66 residues, 63759659-63759851Exon113: 31 residues, 63760931-63761018Exon114: 18 residues, 63761466-63761516Exon115: 373 residues, 63761789-63762903Exon116: 2 residues, -Jump to SYNE2_HUMANExon1: 54 residues, 63389453-63389614Exon2: 45 residues, 63445568-63445698Exon3: 22 residues, 63477084-63477146Exon4: 34 residues, 63478165-63478261Exon5: 28 residues, 63478355-63478433Exon6: 33 residues, 63478521-63478614Exon7: 62 residues, 63486295-63486477Exon8: 67 residues, 63491189-63491386Exon9: 35 residues, 63497995-63498096Exon10: 36 residues, 63500369-63500471Exon11: 48 residues, 63504179-63504317Exon12: 57 residues, 63513033-63513198Exon13: 39 residues, 63514375-63514488Exon14: 56 residues, 63515322-63515485Exon15: 28 residues, 63517124-63517203Exon16: 64 residues, 63517456-63517644Exon17: 57 residues, 63519100-63519265Exon18: 51 residues, 63520210-63520357Exon19: 56 residues, 63522926-63523088Exon20: 55 residues, 63526881-63527040Exon21: 60 residues, 63527412-63527586Exon22: 47 residues, 63530305-63530440Exon23: 55 residues, 63531514-63531673Exon24: 72 residues, 63533417-63533629Exon25: 32 residues, 63533771-63533862Exon26: 38 residues, 63534689-63534799Exon27: 44 residues, 63535384-63535511Exon28: 54 residues, 63537032-63537190Exon29: 51 residues, 63538404-63538552Exon30: 205 residues, 63539190-63539801Exon31: 62 residues, 63543513-63543693Exon32: 52 residues, 63546436-63546587Exon33: 55 residues, 63552943-63553102Exon34: 56 residues, 63554065-63554227Exon35: 36 residues, 63556462-63556564Exon36: 69 residues, 63557785-63557986Exon37: 59 residues, 63558327-63558499Exon38: 39 residues, 63559221-63559334Exon39: 69 residues, 63560727-63560930Exon40: 42 residues, 63561382-63561502Exon41: 99 residues, 63561600-63561892Exon42: 52 residues, 63563049-63563201Exon43: 105 residues, 63563954-63564264Exon44: 57 residues, 63566365-63566530Exon45: 116 residues, 63567486-63567828Exon46: 54 residues, 63584470-63584626Exon47: 90 residues, 63586081-63586347Exon48: 702 residues, 63588027-63590128Exon49: 109 residues, 63592414-63592737Exon50: 50 residues, 63599221-63599366Exon51: 75 residues, 63601902-63602121Exon52: 90 residues, 63607115-63607381Exon53: 58 residues, 63610438-63610607Exon54: 54 residues, 63612415-63612571Exon55: 49 residues, 63614936-63615077Exon56: 63 residues, 63616926-63617109Exon57: 48 residues, 63617913-63618051Exon58: 64 residues, 63624141-63624327Exon59: 43 residues, 63626044-63626167Exon60: 63 residues, 63627336-63627519Exon61: 46 residues, 63629819-63629951Exon62: 68 residues, 63634419-63634617Exon63: 27 residues, 63635217-63635292Exon64: 39 residues, 63638402-63638513Exon65: 41 residues, 63643961-63644078Exon66: 79 residues, 63649811-63650042Exon67: 63 residues, 63655897-63656080Exon68: 47 residues, 63657397-63657532Exon69: 42 residues, 63658482-63658604Exon70: 49 residues, 63658756-63658898Exon71: 46 residues, 63661549-63661681Exon72: 53 residues, 63662797-63662950Exon73: 72 residues, 63663068-63663278Exon74: 36 residues, 63664922-63665024Exon75: 42 residues, 63666252-63666372Exon76: 69 residues, 63666518-63666719Exon77: 60 residues, 63668735-63668909Exon78: 46 residues, 63670539-63670671Exon79: 67 residues, 63674257-63674454Exon80: 46 residues, 63676411-63676544Exon81: 63 residues, 63677811-63677994Exon82: 51 residues, 63678412-63678559Exon83: 61 residues, 63680242-63680419Exon84: 54 residues, 63682538-63682694Exon85: 53 residues, 63689034-63689187Exon86: 59 residues, 63695095-63695266Exon87: 45 residues, 63695782-63695913Exon88: 70 residues, 63698542-63698747Exon89: 62 residues, 63699872-63700052Exon90: 44 residues, 63701755-63701881Exon91: 53 residues, 63703703-63703858Exon92: 50 residues, 63703965-63704110Exon93: 33 residues, 63705347-63705442Exon94: 80 residues, 63706698-63706933Exon95: 67 residues, 63711414-63711609Exon96: 44 residues, 63713828-63713954Exon97: 54 residues, 63722894-63723050Exon98: 55 residues, 63725020-63725179Exon99: 57 residues, 63726541-63726708Exon100: 56 residues, 63739271-63739434Exon101: 64 residues, 63745228-63745416Exon102: 52 residues, 63745898-63746049Exon103: 63 residues, 63746412-63746595Exon104: 48 residues, 63748431-63748569Exon105: 67 residues, 63749281-63749476Exon106: 94 residues, 63750664-63750941Exon107: 48 residues, 63752718-63752858Exon108: 40 residues, 63754868-63754983Exon109: 69 residues, 63755678-63755881Exon110: 69 residues, 63756907-63757108Exon111: 45 residues, 63758046-63758175Exon112: 66 residues, 63759659-63759851Exon113: 31 residues, 63760931-63761018Exon114: 17 residues, 63761469-63761516Exon115: 373 residues, 63761789-63762903Exon116: 2 residues, -Jump to SYNE2_HUMANExon1: 50 residues, 63389465-63389614Exon2: 45 residues, 63445568-63445698Exon3: 22 residues, 63477084-63477146Exon4: 34 residues, 63478165-63478261Exon5: 28 residues, 63478355-63478433Exon6: 33 residues, 63478521-63478614Exon7: 62 residues, 63486295-63486477Exon8: 67 residues, 63491189-63491386Exon9: 35 residues, 63497995-63498096Exon10: 36 residues, 63500369-63500471Exon11: 48 residues, 63504179-63504317Exon12: 57 residues, 63513033-63513198Exon13: 39 residues, 63514375-63514488Exon14: 56 residues, 63515322-63515485Exon15: 28 residues, 63517124-63517203Exon16: 64 residues, 63517456-63517644Exon17: 57 residues, 63519100-63519265Exon18: 51 residues, 63520210-63520357Exon19: 56 residues, 63522926-63523088Exon20: 55 residues, 63526881-63527040Exon21: 60 residues, 63527412-63527586Exon22: 47 residues, 63530305-63530440Exon23: 55 residues, 63531514-63531673Exon24: 72 residues, 63533417-63533629Exon25: 32 residues, 63533771-63533862Exon26: 38 residues, 63534689-63534799Exon27: 44 residues, 63535384-63535511Exon28: 54 residues, 63537032-63537190Exon29: 51 residues, 63538404-63538552Exon30: 205 residues, 63539190-63539801Exon31: 62 residues, 63543513-63543693Exon32: 52 residues, 63546436-63546587Exon33: 55 residues, 63552943-63553102Exon34: 56 residues, 63554065-63554227Exon35: 36 residues, 63556462-63556564Exon36: 69 residues, 63557785-63557986Exon37: 59 residues, 63558327-63558499Exon38: 39 residues, 63559221-63559334Exon39: 69 residues, 63560727-63560930Exon40: 42 residues, 63561382-63561502Exon41: 99 residues, 63561600-63561892Exon42: 52 residues, 63563049-63563201Exon43: 105 residues, 63563954-63564264Exon44: 57 residues, 63566365-63566530Exon45: 116 residues, 63567486-63567828Exon46: 54 residues, 63584470-63584626Exon47: 90 residues, 63586081-63586347Exon48: 702 residues, 63588027-63590128Exon49: 109 residues, 63592414-63592737Exon50: 50 residues, 63599221-63599366Exon51: 75 residues, 63601902-63602121Exon52: 90 residues, 63607115-63607381Exon53: 58 residues, 63610438-63610607Exon54: 54 residues, 63612415-63612571Exon55: 49 residues, 63614936-63615077Exon56: 63 residues, 63616926-63617109Exon57: 48 residues, 63617913-63618051Exon58: 64 residues, 63624141-63624327Exon59: 43 residues, 63626044-63626167Exon60: 63 residues, 63627336-63627519Exon61: 46 residues, 63629819-63629951Exon62: 68 residues, 63634419-63634617Exon63: 27 residues, 63635217-63635292Exon64: 39 residues, 63638402-63638513Exon65: 41 residues, 63643961-63644078Exon66: 79 residues, 63649811-63650042Exon67: 63 residues, 63655897-63656080Exon68: 47 residues, 63657397-63657532Exon69: 42 residues, 63658482-63658604Exon70: 49 residues, 63658756-63658898Exon71: 46 residues, 63661549-63661681Exon72: 53 residues, 63662797-63662950Exon73: 72 residues, 63663068-63663278Exon74: 36 residues, 63664922-63665024Exon75: 42 residues, 63666252-63666372Exon76: 69 residues, 63666518-63666719Exon77: 60 residues, 63668735-63668909Exon78: 46 residues, 63670539-63670671Exon79: 67 residues, 63674257-63674454Exon80: 46 residues, 63676411-63676544Exon81: 63 residues, 63677811-63677994Exon82: 51 residues, 63678412-63678559Exon83: 61 residues, 63680242-63680419Exon84: 54 residues, 63682538-63682694Exon85: 53 residues, 63689034-63689187Exon86: 59 residues, 63695095-63695266Exon87: 45 residues, 63695782-63695913Exon88: 70 residues, 63698542-63698747Exon89: 62 residues, 63699872-63700052Exon90: 44 residues, 63701755-63701881Exon91: 53 residues, 63703703-63703858Exon92: 50 residues, 63703965-63704110Exon93: 33 residues, 63705347-63705442Exon94: 80 residues, 63706698-63706933Exon95: 67 residues, 63711414-63711609Exon96: 44 residues, 63713828-63713954Exon97: 54 residues, 63722894-63723050Exon98: 55 residues, 63725020-63725179Exon99: 57 residues, 63726541-63726708Exon100: 56 residues, 63739271-63739434Exon101: 64 residues, 63745228-63745416Exon102: 52 residues, 63745898-63746049Exon103: 63 residues, 63746412-63746595Exon104: 48 residues, 63748431-63748569Exon105: 67 residues, 63749281-63749476Exon106: 94 residues, 63750664-63750941Exon107: 48 residues, 63752718-63752858Exon108: 40 residues, 63754868-63754983Exon109: 69 residues, 63755678-63755881Exon110: 69 residues, 63756907-63757108Exon111: 45 residues, 63758046-63758175Exon112: 66 residues, 63759659-63759851Exon113: 31 residues, 63760931-63761018Exon114: 18 residues, 63761466-63761516Exon115: 373 residues, 63761789-63762903Exon116: 2 residues, -Jump to SYNE2_HUMAN  
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