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0SYN3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSYN3
DescriptionSynapsin-3 (synapsin iii).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0008021 synaptic vesicle (TAS)
0007269 neurotransmitter secretion (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Synapsins are neuronal phosphoproteins that coat synaptic vesicles.ind to several elements of the cytoskeleton (including actin filaments).nd are believed to function in the regulation of neurotransmitter release . The synapsin family currently includes the highly related synapsin I and II. Both synapsins exist in two alternatively spliced variants.A and IB and IIA and IIB.hat only differ at the C-terminus. It also includes synapsin III.
  IPR001359:Synapsin
InterPro domains unassigned to SynO:
The ATP-grasp fold is one of several distinct ATP-binding folds.nd is found in enzymes that catalyze the formation of amide bonds.atalyzing the ATP-dependent ligation of a carboxylate-containing molecule to an amino or thiol group-containing molecule . This fold is found in many different enzyme families.ncluding various peptide synthetases.iotin carboxylase.ynapsin.uccinyl-CoA synthetase.yruvate phosphate dikinase.nd glutathione synthetase.mongst others . These enzymes contribute predominantly to macromolecular synthesis.sing ATP-hydrolysis to activate their substrates. The ATP-grasp fold shares functional and structural similarities with the PIPK (phosphatidylinositol phosphate kinase) and protein kinase superfamilies. The ATP-grasp domain consists of two subdomains with different alpha+beta folds.hich grasp the ATP molecule between them. Each subdomain provides a variable loop that forms part of the active site.ith regions from other domains also contributing to the active site.ven though these other domains are not conserved between the various ATP-grasp enzymes . This entry represents subdomain 2 found at the C-terminal end of the ATP-grasp domain (the N-terminal subdomain is represented by ().
  IPR013816:ATP-grasp fold, subdomain 2
IPR001359:Synapsin_C 
Evalue:-159.275726318359 
Location:193-395IPR001359:Synapsin_N 
Evalue:-72.3872146606445 
Location:87-191IPR001359:SYNAPSIN_1 
Evalue:0 
Location:4-11
SequencesProtein: SYN3_HUMAN (580 aa)
mRNA: AB209684 BC075065 NM_003490
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords,domains)
The formation of a synapse.
sdb:0034 synaptogenesis  (Evidence:keywords,domains)
A process thaulation of t modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.
sdb:0041 regulation of short-term neuronal synaptic plasticity  (Evidence:keywords,domains)
Penetrating at least one phospholipid bilayer of a synaptic vesicle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
sdb:0078 integral to synaptic vesicle membrane proteins  (Evidence:keywords,domains)
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords,domains)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
?
sdb:0329 actin in synaptic vesicle cycling  (Evidence:keywords,domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 425 residues, 31238539-31239811Exon2: 99 residues, 31244029-31244321Exon3: 31 residues, 31253904-31253992Exon4: 47 residues, 31254860-31254995Exon5: 36 residues, 31259778-31259881Exon6: 27 residues, 31264021-31264098Exon7: 49 residues, 31267558-31267699Exon8: 23 residues, 31322659-31322722Exon9: 32 residues, 31590901-31590991Exon10: 55 residues, 31594952-31595112Exon11: 32 residues, 31657374-31657466Exon12: 21 residues, 31706629-31706687Exon13: 117 residues, 31732336-31732683Exon14: 2 residues, -Jump to SYN3_HUMANExon1: 138 residues, 31239399-31239811Exon2: 99 residues, 31244029-31244321Exon3: 31 residues, 31253904-31253992Exon4: 47 residues, 31254860-31254995Exon5: 36 residues, 31259778-31259881Exon6: 27 residues, 31264021-31264096Exon7: 49 residues, 31267556-31267699Exon8: 23 residues, 31322659-31322722Exon9: 32 residues, 31590901-31590991Exon10: 54 residues, 31594952-31595109Exon11: 32 residues, 31657374-31657466Exon12: 21 residues, 31706629-31706687Exon13: 159 residues, 31732336-31732809Exon14: 19 residues, 31784277-31784329Exon15: 2 residues, -Jump to SYN3_HUMANExon1: 57 residues, 31239643-31239811Exon2: 99 residues, 31244029-31244321Exon3: 31 residues, 31253904-31253992Exon4: 47 residues, 31254860-31254995Exon5: 36 residues, 31259778-31259881Exon6: 27 residues, 31264021-31264096Exon7: 49 residues, 31267556-31267699Exon8: 23 residues, 31322659-31322722Exon9: 32 residues, 31590901-31590991Exon10: 55 residues, 31594952-31595112Exon11: 32 residues, 31657374-31657466Exon12: 21 residues, 31706629-31706687Exon13: 114 residues, 31732336-31732673Exon14: 2 residues, -Jump to SYN3_HUMAN