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0SUOX_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSUOX
DescriptionSulfite oxidase, mitochondrial precursor (ec 1.8.3.1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0008482 sulfite oxidase activity (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
A number of different eukaryotic oxidoreductases that require and bind a molybdopterin cofactor have been shown to share a few regions of sequence similarity. These enzymes include xanthine dehydrogenase ().ldehyde oxidase ().itrate reductase ().nd sulphite oxidase (). The multidomain redox enzyme NAD(P)H:nitrate reductase (NR) catalyzes the reduction of nitrate to nitrite in a single polypeptide electron transport chain with electron flow from NAD(P)H-FAD-cytochrome b5-molybdopterin-NO(3). Three forms of NR are known.n NADH-specific enzyme found in higher plants and algae (); an NAD(P)H-bispecific enzyme found in higher plants.lgae and fungi (); and an NADPH-specific enzyme found only in fungi () . The mitochondrial enzyme sulphite oxidase (sulphite:ferricytochrome c oxidoreductase; EC 1.8.2.1) catalyses oxidation of sulphite to sulphate.sing cytochrome c as the physiological electron acceptor. Sulphite oxidase consists of 2 structure/function domains.n N-terminal heme domain.imilar to cytochrome b5; and a C-terminal molybdopterin domain .
  IPR000572:Oxidoreductase, molybdopterin binding
This domain is found in molybdopterin cofactor (Mo-co) oxidoreductases. It is involved in dimer formation.nd has an Ig-fold structure .
  IPR005066:Mo-co oxidoreductase dimerisation domain
Cytochromes b5 are ubiquitous electron transport proteins found in animals.lants andyeasts . The microsomal and mitochondrial variants are membrane-bound.hile those from erythrocytes and other animal tissues are water-soluble . The 3D structure of bovine cyt b5 is known.hefold belonging to the alpha+beta class.ith 5 strands and 5 short helicesforming a framework for supporting a central haem group . The cytochrome b5 domain is similar to that of a numberof oxidoreductases.uch as plant and fungal nitrate reductases.ulphite oxidase.eastflavocytochrome b2 (L-lactate dehydrogenase) and plant cyt b5/acyl lipid desaturasefusion protein.
  IPR001199:Cytochrome b5
A number of different eukaryotic oxidoreductases that require and bind a molybdopterin cofactor have been shown to share a few regions of sequence similarity. These enzymes include xanthine dehydrogenase ().ldehyde oxidase ().itrate reductase ().nd sulphite oxidase (). The multidomain redox enzyme NAD(P)H:nitrate reductase (NR) catalyzes the reduction of nitrate to nitrite in a single polypeptide electron transport chain with electron flow from NAD(P)H-FAD-cytochrome b5-molybdopterin-NO(3). Three forms of NR are known.n NADH-specific enzyme found in higher plants and algae (); an NAD(P)H-bispecific enzyme found in higher plants.lgae and fungi (); and an NADPH-specific enzyme found only in fungi () . The mitochondrial enzyme sulphite oxidase (sulphite:ferricytochrome c oxidoreductase; ) catalyses oxidation of sulphite to sulphate.sing cytochrome c as the physiological electron acceptor. Sulphite oxidase consists of 2 structure/function domains.n N-terminal heme domain.imilar to cytochrome b5; and a C-terminal molybdopterin domain .Despite functional parallels.embers of the family show no sequence similarity to the C-terminal molybdopterin domain of xanthine dehydrogenase.lthough xanthine dehydrogenase.itrate reductases and sulphite oxidase all contain the eukaryotic molybdopterin oxidoreductases signature. Sequence comparison suggests that only a single Cys residue (Cys186 in chicken sulphite oxidase).s invariant in all these enzymes.ndicating that it may play a role in binding molybdopterin to the protein .
  IPR008335:Eukaryotic molybdopterin oxidoreductase
IPR000572:Oxred_molyb_bd 
Evalue:-86.4814834594727 
Location:111-364IPR001199:Cyt-b5 
Evalue:-19.7695503234863 
Location:27-104IPR008335:EUMOPTERIN 
Evalue:0 
Location:388-402IPR008335:EUMOPTERIN 
Evalue:0 
Location:467-480IPR008335:EUMOPTERIN 
Evalue:0 
Location:452-464IPR008335:EUMOPTERIN 
Evalue:0 
Location:427-437
SequencesProtein: SUOX_HUMAN (488 aa)
mRNA: BC065193 NM_000456
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00387
  Level 3 annotation:
    sulfite oxidase
  Level 2 annotation:
    Sulfur metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 28 residues, 54677309-54677390Exon2: 38 residues, 54677665-54677774Exon3: 44 residues, 54679383-54679509Exon4: 22 residues, 54682262-54682322Exon5: 61 residues, 54682593-54682771Exon6: 637 residues, 54683668-54685574Exon7: 2 residues, -Jump to SUOX_HUMANExon1: 37 residues, 54677664-54677774Exon2: 22 residues, 54682262-54682322Exon3: 61 residues, 54682593-54682771Exon4: 637 residues, 54683668-54685574Exon5: 2 residues, -Jump to SUOX_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2763 54396087-54399754 ~-4K 9024(BLOC1S1)(+)Loci: 2764 54423333-54430331 ~-7K 9030(GDF11)(+)Loci: 2765 54654128-54674745 ~-21K 9056(RAB5B)(+)Loci: 2766 54677309-54685574 ~-8K 9057(SUOX)(+)Loci: 2767 54798296-54802545 ~-4K 9067(+)Loci: 4051 54843395-54869544 ~-26K 9082(SMARCC2)(-)Loci: 4052 54951749-54980442 ~-29K 9095(CS)(-)Loci: 4053 55151003-55168448 ~-17K 9108(GLS2)(-)Loci: 4054 55275981-55316430 ~-40K 9114(BAZ2A)(-)Loci: 4055 55318225-55326119 ~-8K 9115(ATP5B)(-)Loci: 4056 55708568-55730160 ~-22K 9128(MYO1A)(-)Loci: 4050 54364622-54387894 ~-23K 9022(ITGA7)(-)Link out to UCSC