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0SUCB2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSUCLG2
DescriptionSuccinyl-coa ligase beta-chain, mitochondrial precursor (ec 6.2.1.4) (succinyl-coa synthetase, betag chain) (scs-betag) (gtp- specific succinyl-coa synthetase beta subunit).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004776 succinate-CoA ligase (GDP-forming) activity (NAS)
0006104 succinyl-CoA metabolism (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The ATP-grasp superfamily currently includes 17 groups of enzymes.atalyzingATP-dependent ligation of a carboxylate containing molecule to an amino orthiol group-containing molecule . They contribute predominantly to macromolecular synthesis. ATP-hydrolysis is used to activate a substrate. For example.D-ligase transfers phosphate from ATP to D-alanine on the first step of catalysis. On the second step the resulting acylphosphate is attacked by a second D-alanine to produce a DD dipeptide following phosphate elimination .The ATP-grasp domain contains three conserved motifs.orresponding to thephosphate binding loop and the Mg(2+) binding site . The fold is characterized by two alpha-beta subdomains that grasp the ATP molecule between them. Each subdomain provides a variable loop that forms a part of the active site.ompleted by region of other domains not conserved between the various ATP-grasp enzymes .The ATP-grasp domain represented by this entry is found primarily in succinyl-CoA synthetases ().
  IPR013650:ATP-grasp fold, succinyl-CoA synthetase-type
This domain includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains.alate CoA ligase and ATP-citrate lyase. Some members of the domain utilise ATP others use GTP.
  IPR005811:ATP-citrate lyase/succinyl-CoA ligase
There are four different enzymes that share a similar catalytic mechanism which involves the phosphorylation by ATP (or GTP) of a specific histidine residue in the active site. These enzymes are: ATP citrate-lyase () .he primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues.atalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with the concomitant hydrolysis of ATP to ADP and phosphate. ATP-citrate lyase is a tetramer of identical subunits; Succinyl-CoA ligase (GDP-forming) () is a mitochondrial enzyme that catalyzes the substrate level phosphorylation step of the tricarboxylic acid cycle: the formation of succinyl-CoA from succinate with a concomitant hydrolysis of GTP to GDP and phosphate. This enzyme is a dimer composed of an alpha and a beta subunits; Succinyl-CoA ligase (ADP-forming) () is a bacterial enzyme that during aerobic metabolism functions in the citric acid cycle.oupling the hydrolysis of succinyl-CoA to the synthesis of ATP. It can also function in the other direction for anabolic purposes. This enzyme is a tetramer composed of two alpha and two beta subunits; and Malate-CoA ligase () (malyl-CoA synthetase) .s a bacterial enzyme that forms malyl-CoA from malate and CoA with the concomitant hydrolysis of ATP to ADP and phosphate. Malate-CoA ligase is composed of two different subunits.This entry corresponds to a conserved region located in the first half of ATP citrate lyase and in the beta subunits of succinyl-CoA ligases and malate-CoA ligase.
  IPR005809:Succinyl-CoA synthetase, beta subunit
The ATP-grasp fold is one of several distinct ATP-binding folds.nd is found in enzymes that catalyze the formation of amide bonds.atalyzing the ATP-dependent ligation of a carboxylate-containing molecule to an amino or thiol group-containing molecule . This fold is found in many different enzyme families.ncluding various peptide synthetases.iotin carboxylase.ynapsin.uccinyl-CoA synthetase.yruvate phosphate dikinase.nd glutathione synthetase.mongst others . These enzymes contribute predominantly to macromolecular synthesis.sing ATP-hydrolysis to activate their substrates. The ATP-grasp fold shares functional and structural similarities with the PIPK (phosphatidylinositol phosphate kinase) and protein kinase superfamilies. The ATP-grasp domain consists of two subdomains with different alpha+beta folds.hich grasp the ATP molecule between them. Each subdomain provides a variable loop that forms part of the active site.ith regions from other domains also contributing to the active site.ven though these other domains are not conserved between the various ATP-grasp enzymes . This entry represents subdomain 2 found at the C-terminal end of the ATP-grasp domain (the N-terminal subdomain is represented by ().
  IPR013816:ATP-grasp fold, subdomain 2
IPR013650:ATP-grasp_2 
Evalue:-136.468521118164 
Location:39-247IPR005811:Ligase_CoA 
Evalue:-85.5850296020508 
Location:290-426IPR011761:ATP_GRASP 
Evalue:0 
Location:0-0
SequencesProtein: SUCB2_HUMAN (432 aa)
mRNA: BC068602 NM_003848
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK01900
  Level 3 annotation:
    succinate--CoA ligase (GDP-forming) beta chain
  Level 2 annotation:
    Citrate cycle (TCA cycle)
    Propanoate metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 380 residues, 67507835-67508973Exon2: 42 residues, 67533844-67533965Exon3: 49 residues, 67628911-67629054Exon4: 56 residues, 67631247-67631409Exon5: 34 residues, 67641920-67642017Exon6: 32 residues, 67651360-67651450Exon7: 53 residues, 67653595-67653748Exon8: 32 residues, 67661245-67661336Exon9: 35 residues, 67662200-67662300Exon10: 49 residues, 67742568-67742710Exon11: 29 residues, 67787616-67787698Exon12: 2 residues, -Jump to SUCB2_HUMANExon1: 380 residues, 67507835-67508973Exon2: 42 residues, 67533844-67533965Exon3: 49 residues, 67628911-67629054Exon4: 56 residues, 67631247-67631409Exon5: 34 residues, 67641920-67642017Exon6: 32 residues, 67651360-67651450Exon7: 53 residues, 67653595-67653748Exon8: 32 residues, 67661245-67661336Exon9: 35 residues, 67662200-67662300Exon10: 49 residues, 67742568-67742710Exon11: 39 residues, 67787616-67787728Exon12: 2 residues, -Jump to SUCB2_HUMAN  
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