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0SUCA_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSUCLG1
DescriptionSuccinyl-coa ligase alpha-chain, mitochondrial precursor (ec 6.2.1.4) (succinyl-coa synthetase, alpha chain) (scs-alpha).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains.alate CoA ligase and ATP-citrate lyase. Some members of the domain utilise ATP others use GTP.
  IPR005811:ATP-citrate lyase/succinyl-CoA ligase
This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases.alate and ATP-citrate ligases.
  IPR003781:CoA-binding
There are four different enzymes that share a similar catalytic mechanism which involves the phosphorylation by ATP (or GTP) of a specific histidine residue in the active site. These enzymes are: ATP citrate-lyase () .he primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues.atalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with the concomitant hydrolysis of ATP to ADP and phosphate. ATP-citrate lyase is a tetramer of identical subunits; Succinyl-CoA ligase (GDP-forming) () is a mitochondrial enzyme that catalyzes the substrate level phosphorylation step of the tricarboxylic acid cycle: the formation of succinyl-CoA from succinate with a concomitant hydrolysis of GTP to GDP and phosphate. This enzyme is a dimer composed of an alpha and a beta subunits; Succinyl-CoA ligase (ADP-forming) () is a bacterial enzyme that during aerobic metabolism functions in the citric acid cycle.oupling the hydrolysis of succinyl-CoA to the synthesis of ATP. It can also function in the other direction for anabolic purposes. This enzyme is a tetramer composed of two alpha and two beta subunits; and Malate-CoA ligase () (malyl-CoA synthetase) .s a bacterial enzyme that forms malyl-CoA from malate and CoA with the concomitant hydrolysis of ATP to ADP and phosphate. Malate-CoA ligase is composed of two different subunits.This entry corresponds to two regions. glycine-rich conserved region.ocated in the second half of ATP citrate lyase and in the alpha subunits of succinyl-CoA ligases and malate-CoA ligase; and the active site phosphorylated histidine residue.hich is located some 50 residues to the C-terminal of the first region.
  IPR005810:Succinyl-CoA ligase, alpha subunit
IPR005811:Ligase_CoA 
Evalue:-67.4202194213867 
Location:168-313IPR003781:CoA_binding 
Evalue:-53.5850257873535 
Location:38-134
SequencesProtein: SUCA_HUMAN (333 aa)
mRNA: NM_003849
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK01899
  Level 3 annotation:
    succinate--CoA ligase (GDP-forming) alpha chain
  Level 2 annotation:
    Citrate cycle (TCA cycle)
    Propanoate metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 74 residues, 84504186-84504407Exon2: 65 residues, 84506049-84506238Exon3: 52 residues, 84512142-84512294Exon4: 30 residues, 84513986-84514070Exon5: 21 residues, 84521681-84521739Exon6: 73 residues, 84521881-84522094Exon7: 41 residues, 84523918-84524035Exon8: 36 residues, 84530283-84530387Exon9: 31 residues, 84539807-84539896Exon10: 2 residues, -Jump to SUCA_HUMAN  
Loci Cluster (Details)Loci: 3174 84986273-84987310 ~-1K 20748(TMSB10)(+)Loci: 4455 85398657-85408885 ~-10K 20753(TGOLN2)(-)Loci: 3175 85658227-85662664 ~-4K 20772(VAMP8)(+)Loci: 3176 85665041-85674022 ~-9K 20773(VAMP5)(+)Loci: 4454 84504186-84539896 ~-36K 20743(SUCLG1)(-)Link out to UCSC