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0STXB3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionSyntaxin-binding protein 3 (unc-18 homolog 3) (unc-18c) (unc-18-3) (platelet sec1 protein) (psp).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains assigned to SynO:
Sec1-like molecules have been implicated in a variety of eukaryotic vesicle transport processes including neurotransmitter release by exocytosis . They regulate vesicle transport by binding to a t-SNARE from the syntaxin family. This process is thought to prevent SNARE complex formation. protein complex required for membrane fusion. Whereas Sec1 molecules are essential for neurotransmitter release and other secretory events.heir interaction with syntaxin molecules seems to represent a negative regulatory step in secretion .
  IPR001619:Sec1-like protein
SequencesProtein: STXB3_HUMAN (592 aa)
mRNA: NM_007269
Local Annotation
Synapse Ontology
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords,domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:keywords,domains)
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:keywords,domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 34 residues, 109090830-109090931Exon2: 18 residues, 109096401-109096451Exon3: 29 residues, 109097207-109097289Exon4: 27 residues, 109100834-109100911Exon5: 28 residues, 109102654-109102733Exon6: 35 residues, 109104129-109104230Exon7: 53 residues, 109116809-109116964Exon8: 32 residues, 109120477-109120568Exon9: 43 residues, 109123430-109123555Exon10: 34 residues, 109126566-109126662Exon11: 21 residues, 109126793-109126851Exon12: 24 residues, 109137726-109137792Exon13: 29 residues, 109138971-109139052Exon14: 48 residues, 109140378-109140517Exon15: 37 residues, 109140764-109140871Exon16: 33 residues, 109142289-109142382Exon17: 30 residues, 109144364-109144450Exon18: 51 residues, 109151545-109151694Exon19: 250 residues, 109152927-109153671Exon20: 2 residues, -Jump to STXB3_HUMAN  
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Loci Cluster (Details)Loci: 2532 109221349-109274541 ~-53K 2049(+)Loci: 2533 109594163-109619895 ~-26K 2068(CELSR2)(+)Loci: 3813 109653714-109742086 ~-88K 2077(SORT1)(-)Loci: 2534 109810622-109826277 ~-16K 2079(SYPL2)(+)Loci: 3814 109850969-109853827 ~-3K 2087(AMIGO1)(-)Loci: 2531 109090830-109153671 ~-63K 2044(STXBP3)(+)Link out to UCSC