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0STXB2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSTXBP2
DescriptionSyntaxin binding protein 2 (unc-18 homolog 2) (unc-18b) (unc18-2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0030347 syntaxin-2 binding (NAS)
0030348 syntaxin-3 binding (NAS)
0006886 intracellular protein transport (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Sec1-like molecules have been implicated in a variety of eukaryotic vesicle transport processes including neurotransmitter release by exocytosis . They regulate vesicle transport by binding to a t-SNARE from the syntaxin family. This process is thought to prevent SNARE complex formation. protein complex required for membrane fusion. Whereas Sec1 molecules are essential for neurotransmitter release and other secretory events.heir interaction with syntaxin molecules seems to represent a negative regulatory step in secretion .
  IPR001619:Sec1-like protein
IPR001619:Sec1 
Evalue:-275.39794921875 
Location:28-580
SequencesProtein: STXB2_HUMAN (593 aa)
mRNA: BC002869 NM_006949
Local Annotation
Synapse Ontology
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:keywords,domains)
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:keywords,domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 21 residues, 7608012-7608072Exon2: 18 residues, 7609611-7609661Exon3: 29 residues, 7609904-7609986Exon4: 27 residues, 7610616-7610693Exon5: 25 residues, 7611625-7611695Exon6: 36 residues, 7611785-7611889Exon7: 51 residues, 7612590-7612739Exon8: 30 residues, 7612919-7613004Exon9: 45 residues, 7613088-7613219Exon10: 38 residues, 7613314-7613422Exon11: 21 residues, 7613651-7613709Exon12: 24 residues, 7613868-7613934Exon13: 29 residues, 7614050-7614131Exon14: 48 residues, 7615499-7615638Exon15: 38 residues, 7616082-7616192Exon16: 34 residues, 7617134-7617230Exon17: 30 residues, 7618047-7618133Exon18: 54 residues, 7618239-7618397Exon19: 51 residues, 7618610-7618758Exon20: 2 residues, -Jump to STXB2_HUMANExon1: 18 residues, 7608020-7608072Exon2: 18 residues, 7609611-7609661Exon3: 29 residues, 7609904-7609986Exon4: 27 residues, 7610616-7610693Exon5: 28 residues, 7611616-7611695Exon6: 36 residues, 7611785-7611889Exon7: 51 residues, 7612590-7612739Exon8: 30 residues, 7612919-7613004Exon9: 45 residues, 7613088-7613219Exon10: 38 residues, 7613314-7613422Exon11: 21 residues, 7613651-7613709Exon12: 24 residues, 7613868-7613934Exon13: 29 residues, 7614050-7614131Exon14: 48 residues, 7615499-7615638Exon15: 38 residues, 7616082-7616192Exon16: 34 residues, 7617134-7617230Exon17: 30 residues, 7618047-7618133Exon18: 54 residues, 7618239-7618397Exon19: 31 residues, 7618610-7618697Exon20: 2 residues, -Jump to STXB2_HUMAN  
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Loci Cluster (Details)Loci: 3084 7493511-7504871 ~-11K 17845(MCOLN1)(+)Loci: 3085 7608012-7618758 ~-11K 17854(STXBP2)(+)Loci: 4362 7897603-7914538 ~-17K 17882(TIMM44)(-)Loci: 3086 8361295-8374479 ~-13K 17895(RAB11B)(+)Loci: 4361 7067641-7245011 ~-177K 17833(INSR)(-)Link out to UCSC