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0STX18_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSTX18
DescriptionSyntaxin-18.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005783 endoplasmic reticulum (TAS)
0006888 ER to Golgi transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Soluble N-ethylmaleimide attachment protein receptor (SNARE) proteins are a family of membrane-associated proteins characterised by an alpha-helical coiled-coil domain called the SNARE motif . These proteins are classified as v-SNAREs and t-SNAREs based on their localisation on vesicle or target membrane; another classification scheme defines R-SNAREs and Q-SNAREs.s based on the conserved arginine or glutamine residue in the centre of the SNARE motif. SNAREs are localised to distinct membrane compartments of the secretory and endocytic trafficking pathways.nd contribute to the specificity of intracellular membrane fusion processes.The t-SNARE domain consists of a 4-helical bundle with a coiled-coil twist. The SNARE motif contributes to the fusion of two membranes. SNARE motifs fall into four classes: homologues of syntaxin 1a (t-SNARE).AMP-2 (v-SNARE).nd the N- and C-terminal SNARE motifs of SNAP-25. It is thought that one member from each class interacts to form a SNARE complex.The SNARE motif represented in this entry is found in the N-terminal domains of certain syntaxin family members: syntaxin 1a.hich is required for neurotransmitter release.yntaxin 6.hich is found in endosomal transport vesicles .east Sso1p .nd Vam3p. yeast syntaxin essential for vacuolar fusion . The SNARE motifs in these proteins share structural similarity.espite having a low level of sequence similarity.
  IPR010989:t-snare
IPR010989:t-snare 
Evalue:0 
Location:44-297IPR000727:T_SNARE 
Evalue:0 
Location:0-0
SequencesProtein: STX18_HUMAN (335 aa)
mRNA: NM_016930
Local Annotation
Synapse Ontology
Fusion of intracellular membrane-bound vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
sdb:0049 synaptic vesicle fusion  (Evidence:keywords,domains)
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords,domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:keywords,domains)
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 387 residues, 4471598-4472757Exon2: 29 residues, 4473491-4473572Exon3: 25 residues, 4476145-4476215Exon4: 21 residues, 4477791-4477850Exon5: 31 residues, 4487397-4487486Exon6: 40 residues, 4491021-4491137Exon7: 24 residues, 4509818-4509885Exon8: 28 residues, 4510050-4510128Exon9: 40 residues, 4511999-4512115Exon10: 24 residues, 4524266-4524334Exon11: 86 residues, 4594424-4594676Exon12: 2 residues, -Jump to STX18_HUMAN  
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Loci Cluster (Details)Loci: 4662 4471598-4594676 ~-123K 27292(STX18)(-)Loci: 3404 4439652-4471685 ~-32K 27291(NSG1)(+)Link out to UCSC