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0SSR3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSSTR3
DescriptionSomatostatin receptor type 3 (ss3r) (ssr-28).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0004994 somatostatin receptor activity (TAS)
0007267 cell-cell signaling (TAS)
0007187 G-protein signaling, coupled to cyclic nucl... (TAS)
0008628 induction of apoptosis by hormones (TAS)
0008285 negative regulation of cell proliferation (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Somatostatin is a neurotransmitter/hormone with a wide range of biologialfunctions . It has an important role in the neuroendocrine system andinhibits secretion of growth hormone and prolactin in the anteriorpituitary. It also inhibits secretion in the intestine (including gastricacid in the stomach).ancreatic acinar cells and pancreatic beta-cells.timulates absorption in the intestine and modulates smooth musclecontractility. In the CNS.t is a neurotransmitter activating a hyperpolarising K+ current and inhibiting Ca2+ influx.nd is believed toplay important roles in regulating locomotor activity and cognitivefunction. Receptor subtypes were originally proposed on the basis offunctional and radio-ligand binding studies.nd cloning has now confirmedthe presence of at least 4 subtypes.
  IPR000586:Somatostatin receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Somatostatin is a neurotransmitter/hormone with a wide range of biologialfunctions . It has an important role in the neuroendocrine system andinhibits secretion of growth hormone and prolactin in the anteriorpituitary. It also inhibits secretion in the intestine (including gastricacid in the stomach).ancreatic acinar cells and pancreatic beta-cells.timulates absorption in the intestine and modulates smooth musclecontractility. In the CNS.t is a neurotransmitter activating a hyperpolarising K+ current and inhibiting Ca2+ influx.nd is believed toplay important roles in regulating locomotor activity and cognitivefunction. Receptor subtypes were originally proposed on the basis offunctional and radio-ligand binding studies.nd cloning has now confirmedthe presence of at least 4 subtypes.The SS3 receptor mRNA is widely distributed in mouse brain.ith highlevels in the forebrain.ippocampus and amygdala; moderate levels are alsopresent in the substantia nigra. The receptors inhibit adenylyl cyclasethrough a pertussis-toxin-sensitive G-protein.robably belonging to theGi/Go class .
  IPR001856:Somatostatin receptor, type 3
IPR000276:7tm_1 
Evalue:-82.3098068237305 
Location:61-313IPR001856:SOMATOSTTN3R 
Evalue:0 
Location:322-340IPR001856:SOMATOSTTN3R 
Evalue:0 
Location:12-30IPR001856:SOMATOSTTN3R 
Evalue:0 
Location:32-49IPR001856:SOMATOSTTN3R 
Evalue:0 
Location:395-412
SequencesProtein: SSR3_HUMAN (418 aa)
mRNA: NM_001051
Local Annotation
Synapse Ontology
?
sdb:0219 GPCR mediated signaling  (Evidence:domains)
KO assignmentK04219
  Level 3 annotation:
    somatostatin receptor 3
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 545 residues, 35932191-35933824Exon2: 165 residues, 35937810-35938299Exon3: 2 residues, -Jump to SSR3_HUMAN  
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Loci Cluster (Details)Loci: 3313 36334448-36359516 ~-25K 24689(GGA1)(+)Loci: 3314 36365427-36392885 ~-27K 24693(+)Loci: 3315 36533890-36543129 ~-9K 24705(GCAT)(+)Loci: 3316 36549334-36551448 ~-2K 24707(GALR3)(+)Loci: 3317 36783348-36801653 ~-18K 24722(PRKCABP)(+)Loci: 4568 36810855-36836622 ~-26K 24725(-)Loci: 4569 37152280-37181149 ~-29K 24733(KCNJ4)(-)Loci: 4570 37209390-37232262 ~-23K 24737(DDX17)(-)Loci: 4571 37460680-37481928 ~-21K 24750(UNC84B)(-)Loci: 4567 35932191-35938299 ~-6K 24676(SSTR3)(-)Link out to UCSC